Product image of Metoject (Methotrexate) supplied by GNH India

Metoject

Active Ingredient:
Methotrexate
Origin:
EU

Metoject (Methotrexate)

Methotrexate, the active ingredient in Metoject, is an antimetabolite (folate antagonist) presented as a solution for subcutaneous injection for subcutaneous use. It treats rheumatoid arthritis, psoriasis, severe plaque psoriasis, and certain malignancies such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma in appropriate patients.

GNH India supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)

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Indications & Clinical Uses

Methotrexate is a folate antagonist used in several immune‑mediated and oncologic conditions.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis (including severe plaque psoriasis): decreases skin cell proliferation and inflammation.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication as part of chemotherapy protocols.
  • Non‑Hodgkin lymphoma: contributes to tumor control when combined with other agents.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, leading to reduced tetrahydrofolate synthesis. This limits the availability of one‑carbon units required for purine and pyrimidine synthesis, thereby impairing DNA, RNA and protein production in rapidly dividing cells. The resulting antiproliferative effect modulates immune cell activity and cancer cell growth.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Fatigue: general tiredness.
  • Mouth sores: ulceration of oral mucosa.
  • Elevated liver enzymes: mild hepatic irritation.
  • Low blood counts: mild leukopenia or anemia.

Serious or Rare Side Effects

  • Severe liver toxicity: potential hepatitis or fibrosis.
  • Pulmonary fibrosis: interstitial lung disease.
  • Severe bone marrow suppression: pancytopenia.
  • Renal impairment: acute kidney injury.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing methotrexate, several precautions should be observed to minimize risks.

  • Pregnancy contraindication: avoid use in pregnancy (Category X) and discontinue well before conception.
  • Renal function monitoring: assess creatinine before initiation and periodically.
  • Liver function monitoring: perform baseline and regular liver enzyme tests.
  • Hematologic monitoring: check complete blood count regularly.
  • Concomitant NSAIDs caution: avoid combined use without supervision due to increased toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Live vaccines: may cause severe infection.
  • High-dose aspirin or NSAIDs: increase methotrexate toxicity.
  • Trimethoprim‑sulfamethoxazole: can enhance myelosuppression.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may increase serum methotrexate levels.
  • Azathioprine or other immunosuppressants: additive bone marrow suppression.
  • Oral contraceptives: may reduce methotrexate clearance.

Frequently Asked Questions

Metoject contains methotrexate, which is prescribed for rheumatoid arthritis, psoriasis (including severe plaque forms), and certain cancers such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma. It works as a disease‑modifying antirheumatic drug and as part of chemotherapy regimens.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing the production of tetrahydrofolate. This limits the synthesis of nucleotides needed for DNA, RNA and protein formation, thereby inhibiting the growth of rapidly dividing cells and modulating immune responses.

The dose of Metoject is individualized by the prescribing clinician based on the specific indication, patient weight, renal function and treatment goals. Only a qualified health‑care professional should determine the appropriate dosing schedule.

Metoject is classified as pregnancy category X, meaning it is contraindicated in pregnancy because of a high risk of fetal harm. It is also not recommended while breastfeeding, as methotrexate can be excreted in breast milk and affect the infant.

To order Metoject, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Both methotrexate (Metoject) and leflunomide are DMARDs used for rheumatoid arthritis, but methotrexate is generally considered first‑line because of its extensive efficacy data and cost profile. Leflunomide may be chosen when patients cannot tolerate methotrexate or when combination therapy is needed.

Metoject should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Metoject is supplied as a sterile solution for subcutaneous injection. It is typically injected into the abdomen or thigh using a pre‑filled syringe or a suitable needle, following the technique instructed by the health‑care provider.

Serious risks include severe liver toxicity, pulmonary fibrosis, profound bone‑marrow suppression leading to pancytopenia, renal impairment, and life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for these complications.

Metoject should not be used by pregnant or breastfeeding individuals, patients with severe renal or hepatic impairment, those with known hypersensitivity to methotrexate, or anyone receiving live vaccines without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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