Product image of Metoklopramid-Hidroklorid Noridem (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoklopramid-Hidroklorid Noridem

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoklopramid-Hidroklorid Noridem (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride, the active ingredient in Metoklopramid-Hidroklorid Noridem, is a dopamine D2 receptor antagonist presented as a sterile injectable solution for intramuscular or intravenous use. It is employed to manage nausea, vomiting and gastric motility disorders in adult patients.

GNH India supplies Metoklopramid-Hidroklorid Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metoclopramide Hydrochloride acts on the gastrointestinal and central nervous systems to control emesis and improve gastric emptying.

  • Post‑operative nausea and vomiting: reduces the frequency and severity of nausea after surgery.
  • Chemotherapy‑induced nausea and vomiting: helps prevent acute emesis associated with cytotoxic agents.
  • Gastroparesis: enhances gastric motility to alleviate delayed gastric emptying.
  • Gastro‑oesophageal reflux disease: facilitates lower oesophageal sphincter tone and gastric emptying.
  • Facilitation of gastric emptying before diagnostic procedures: improves tolerance of imaging studies requiring an empty stomach.

How It Works

  • Metoclopramide Hydrochloride competitively blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal smooth muscle, while also antagonising 5‑HT3 receptors. This dual action increases antral contractility, accelerates gastric emptying, and diminishes the central perception of nausea and vomiting.

Side Effects

Metoclopramide Hydrochloride may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Drowsiness: mild sedation or fatigue.
  • Extrapyramidal symptoms: transient muscle rigidity or tremor.
  • Diarrhoea: increased bowel movements.
  • Restlessness: feeling of inner agitation.
  • Headache: mild to moderate intensity.
  • Hyperprolactinaemia: elevated prolactin leading to breast tenderness.

Serious or Rare Side Effects

  • Tardive dyskinesia: persistent involuntary movements, especially with prolonged use.
  • Neuroleptic malignant syndrome: rare but life‑threatening hyperthermia and rigidity.
  • Severe allergic reaction: anaphylaxis, rash, or angioedema.
  • Cardiac arrhythmias: QT prolongation in susceptible individuals.
  • Depression or suicidal thoughts: mood changes requiring immediate evaluation.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient history and monitor for specific risks.

  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Breastfeeding: consider possible excretion in milk and infant exposure.
  • Renal impairment: adjust dosing or monitor closely in patients with reduced clearance.
  • History of movement disorders: avoid or use with caution in patients with Parkinson’s disease or dystonia.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metoclopramide Hydrochloride can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and serotonin syndrome.
  • Antipsychotics (high‑potency D2 blockers): may potentiate extrapyramidal effects.
  • CYP2D6 substrates (e.g., codeine, tramadol): increased plasma levels and adverse effects.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, opioids): enhanced sedation and respiratory depression.
  • Anticholinergic agents: may reduce pro‑kinetic efficacy.
  • Digoxin: possible increase in serum concentrations.
  • Antihistamines: may augment drowsiness.

Frequently Asked Questions

Metoklopramid-Hidroklorid Noridem, containing metoclopramide hydrochloride, is indicated for the treatment of nausea and vomiting—including postoperative and chemotherapy‑induced cases—gastroparesis, gastro‑oesophageal reflux disease, and to facilitate gastric emptying before certain diagnostic procedures.

Metoclopramide hydrochloride works by competitively blocking dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal smooth muscle, while also antagonising serotonin 5‑HT3 receptors. This dual action enhances gastric motility and reduces the central perception of nausea and vomiting.

The appropriate dose of Metoklopramid-Hidroklorid Noridem is determined by the prescribing clinician based on the specific indication, patient age, renal function and treatment setting. Dosage regimens are individualized and should follow local prescribing guidelines.

Metoclopramide should be used during pregnancy only if the potential benefit outweighs any potential risk to the fetus. It is excreted in breast milk, so caution is advised when administering to nursing mothers, and a risk‑benefit assessment should be performed.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many antiemetics by combining dopamine D2 antagonism with serotonergic (5‑HT3) blockade and pro‑kinetic activity. Unlike pure 5‑HT3 antagonists such as ondansetron, it also enhances gastric emptying, making it useful for conditions like gastroparesis, but it carries a higher risk of extrapyramidal side effects.

Metoklopramid-Hidroklorid Noridem should be stored at controlled room temperature, protected from light and moisture, and kept in its original packaging until use. Do not freeze the product.

The product is supplied as a sterile injectable solution for intramuscular or intravenous administration. The route, rate and duration of injection are determined by the prescriber and should follow aseptic technique and local clinical protocols.

Serious risks include tardive dyskinesia, a potentially irreversible movement disorder, neuroleptic malignant syndrome, severe allergic reactions such as anaphylaxis, and cardiac arrhythmias in susceptible patients. Prompt medical attention is required if any of these occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, and individuals with a history of seizure disorders or severe depression where it may exacerbate symptoms. Caution is also advised in patients with Parkinson’s disease or other extrapyramidal disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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