Product image of Metomylan (Metoprolol Tartrate) supplied by GNH India

Metomylan

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metomylan (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metomylan, is a beta blocker presented as an oral dosage form for oral use. It is employed to lower blood pressure, relieve angina, and improve outcomes in heart failure and certain cardiac arrhythmias in adult patients.

GNH India supplies Metomylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Metomylan is a selective β1‑adrenergic blocker used in several cardiovascular conditions.

  • Hypertension: reduces systolic and diastolic pressure to target levels.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: lowers risk of recurrent infarction and mortality.
  • Heart failure: improves left‑ventricular function and reduces hospitalisation.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other rhythm disorders.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting catecholamine‑induced stimulation of adenylate cyclase. This reduces intracellular cyclic AMP, leading to decreased heart rate, myocardial contractility, and cardiac output, which together lower arterial pressure and myocardial oxygen consumption.

Side Effects

Metomylan may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness, especially on standing.
  • Bradycardia (slow heart rate).
  • Cold extremities or reduced peripheral circulation.
  • Gastrointestinal discomfort such as nausea or abdominal pain.
  • Headache.

Serious or Rare Side Effects

  • Severe bradycardia or heart block requiring medical attention.
  • Marked hypotension leading to syncope.
  • Bronchospasm in patients with asthma or chronic obstructive pulmonary disease.
  • Allergic reactions including rash, pruritus, or angioedema.
  • Depression or mood changes.
  • Worsening heart failure symptoms.

Precautions & Warnings

Before initiating Metomylan, clinicians should consider several safety measures.

  • Heart rate monitoring: assess baseline pulse and watch for excessive slowing.
  • Blood pressure assessment: ensure adequate control before dose escalation.
  • Respiratory evaluation: avoid use in uncontrolled asthma or severe COPD.
  • Renal/hepatic function: adjust dose in patients with impaired clearance.
  • Discontinuation: taper gradually to prevent rebound hypertension or tachycardia.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metomylan can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Verapamil or diltiazem: additive negative chronotropic effect may cause severe bradycardia.
  • Other β‑blockers: risk of excessive β‑blockade and hypotension.
  • Class IA or III antiarrhythmics (e.g., quinidine, amiodarone): may precipitate heart block.
  • Potent CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increase metoprolol plasma levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect.
  • Diuretics: combined use can enhance hypotensive response.
  • Antidiabetic agents: beta‑blockade may mask hypoglycaemia symptoms.
  • Calcium channel blockers (non‑dihydropyridine): monitor for additive cardiac effects.

Frequently Asked Questions

Metomylan contains metoprolol tartrate, a selective β1‑blocker indicated for hypertension, angina pectoris, post‑myocardial infarction management, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It works by lowering heart rate and blood pressure, thereby reducing cardiac workload.

Metoprolol tartrate blocks β1‑adrenergic receptors in the heart, preventing catecholamines from stimulating these receptors. This inhibition reduces cyclic AMP formation, leading to slower heart rate, decreased contractility, and lower cardiac output, which together lower arterial pressure and myocardial oxygen demand.

The appropriate dose of Metomylan is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage may be adjusted over time, and patients should follow the exact regimen provided by their healthcare professional.

Safety data for metoprolol tartrate in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks before prescribing to pregnant or nursing women, and the decision should be made on a case‑by‑case basis.

To request Metomylan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metomylan (metoprolol tartrate) is a cardio‑selective β1‑blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its pharmacokinetic profile provides reliable blood pressure and heart‑rate control, making it a common choice for patients with respiratory comorbidities.

Metomylan should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Metomylan is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing, or swelling of the face or throat.

Metomylan is contraindicated in patients with known hypersensitivity to metoprolol or other β‑blockers, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncompensated heart failure or severe asthma/COPD. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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