Product image of Metopimazine Biogaran (Metopimazine) supplied by GNH India

Metopimazine Biogaran

Active Ingredient:
Metopimazine
Origin:
EU

Metopimazine Biogaran (Metopimazine)

Metopimazine, the active ingredient in Metopimazine Biogaran, is a phenothiazine antiemetic presented as an oral tablet for oral use. It treats nausea and vomiting in adult patients.
GNH India supplies Metopimazine Biogaran as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

Metopimazine is a phenothiazine antiemetic that acts on dopamine pathways to control emesis.

  • Nausea: reduces the frequency and intensity of nausea episodes.
  • Vomiting: helps stop acute vomiting episodes.
  • Post‑operative nausea and vomiting (PONV): prevents or treats nausea and vomiting after surgery.

How It Works

  • Metopimazine exerts its antiemetic activity by competitively antagonising dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This blockade reduces dopaminergic stimulation that normally initiates the vomiting reflex, thereby decreasing nausea and vomiting signals transmitted to the brainstem.

Side Effects

Metopimazine may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Drowsiness: mild to moderate sedation.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: transient light‑headedness.
  • Blurred vision: temporary visual disturbances.
  • Weight gain: modest increase in appetite.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity or tremor.
  • Tardive dyskinesia: persistent involuntary movements.
  • Neuroleptic malignant syndrome: life‑threatening hyperthermia.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Agranulocytosis: severe reduction in white blood cells.

Precautions & Warnings

Before prescribing Metopimazine, clinicians should consider patient‑specific factors and monitor for potential risks.

  • Renal or hepatic impairment: adjust use and monitor function.
  • Elderly patients: start with the lowest effective dose.
  • Known hypersensitivity: avoid if allergic to phenothiazines.
  • Cardiovascular disease: watch for hypotension or arrhythmias.
  • Discontinuation: taper gradually to reduce withdrawal effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metopimazine can interact with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension.
  • CNS depressants (e.g., opioids, benzodiazepines): additive sedation.
  • Antihypertensive agents: may cause excessive blood‑pressure lowering.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: increased anticholinergic burden.
  • QT‑prolonging medications: potential cardiac rhythm disturbances.
  • CYP2D6 inhibitors: may raise Metopimazine plasma levels.
  • Alcohol: enhances central nervous system depression.
  • Other antipsychotics: may increase extrapyramidal risk.

Frequently Asked Questions

Metopimazine Biogaran is an oral phenothiazine antiemetic indicated for the treatment of nausea and vomiting, including postoperative nausea and vomiting, in adult patients. It works by blocking dopamine receptors that trigger the vomiting reflex.

Metopimazine acts as a dopamine D2 receptor antagonist. By inhibiting dopamine signalling in the chemoreceptor trigger zone and the gastrointestinal tract, it reduces the neural signals that initiate nausea and vomiting, providing symptomatic relief.

The dosage of Metopimazine Biogaran is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual response. The prescriber will select the appropriate strength and dosing schedule.

The safety of Metopimazine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metopimazine belongs to the phenothiazine class, differing from serotonin‑type (5‑HT3) antagonists and antihistamines. It primarily blocks dopamine receptors, which can be advantageous in dopamine‑mediated nausea, but may have a higher propensity for extrapyramidal side effects compared with some newer agents.

Metopimazine Biogaran should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Metopimazine Biogaran is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include extrapyramidal symptoms such as dystonia or tardive dyskinesia, neuroleptic malignant syndrome, severe hypotension, cardiac arrhythmias, and rare blood disorders like agranulocytosis. Patients should be monitored for these events, especially during the initial weeks of therapy.

Metopimazine is contraindicated in individuals with known hypersensitivity to phenothiazines, those taking MAO inhibitors, and patients with severe cardiovascular instability. Caution is also advised for patients with a history of extrapyramidal disorders or significant liver or kidney impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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