Product image of Metopimazine Venipharm (Metopimazine) supplied by GNH India

Metopimazine Venipharm

Active Ingredient:
Metopimazine
Origin:
EU

Metopimazine Venipharm (Metopimazine)

Metopimazine, the active ingredient in Metopimazine Venipharm, is a phenothiazine derivative presented as an oral tablet for oral use. It acts as an antiemetic by blocking dopamine D2 receptors in the chemoreceptor trigger zone, helping to control nausea and vomiting in postoperative, chemotherapy, and other settings for patients.

GNH India supplies Metopimazine Venipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Venipharm

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Indications & Clinical Uses

Metopimazine is an antiemetic that works on the dopamine pathway to control nausea and vomiting.

  • Nausea: reduces the sensation of nausea in various clinical situations.
  • Vomiting: limits the frequency and intensity of vomiting episodes.
  • Postoperative nausea and vomiting: helps prevent and treat nausea after surgery.
  • Chemotherapy‑induced nausea and vomiting: mitigates nausea associated with cancer treatment.

How It Works

  • Metopimazine antagonizes dopamine D2 receptors located in the chemoreceptor trigger zone of the brainstem. By blocking dopamine signaling, it diminishes the neural impulses that trigger the vomiting reflex, thereby providing antiemetic protection in situations such as surgery, chemotherapy, and other causes of nausea.

Side Effects

Metopimazine may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild to moderate sedation.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: sensation of light‑headedness.
  • Blurred vision: temporary visual disturbance.
  • Weight gain: modest increase in appetite.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or dystonia.
  • Neuroleptic malignant syndrome: rare but life‑threatening hyperthermia and rigidity.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm, especially in patients with pre‑existing cardiac disease.

Precautions & Warnings

Before prescribing Metopimazine, clinicians should consider several safety aspects.

  • Assess renal function: adjust use in patients with severe impairment.
  • Monitor for extrapyramidal symptoms: watch for muscle rigidity or tremor.
  • Avoid use in patients with known hypersensitivity to phenothiazines.
  • Use caution in cardiovascular disease: risk of hypotension and arrhythmia.
  • Avoid concomitant use with other dopamine antagonists: increased CNS effects.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Avoid Interactions

Metopimazine can interact with other medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive central nervous system depression.
  • MAO inhibitors: risk of hypertensive crisis.
  • QT‑prolonging drugs (e.g., erythromycin): heightened potential for cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: increased anticholinergic burden.
  • CNS depressants (opioids, benzodiazepines): enhanced sedation.
  • CYP2D6 inhibitors (e.g., fluoxetine): possible alteration of Metopimazine plasma levels.

Frequently Asked Questions

Metopimazine Venipharm is prescribed to prevent and treat nausea and vomiting. It is indicated for postoperative nausea and vomiting, chemotherapy‑induced nausea and vomiting, and other situations where dopamine‑mediated emesis occurs.

Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone of the brainstem. This antagonism reduces the neural signals that initiate the vomiting reflex, providing effective antiemetic control.

The dose of Metopimazine is individualized by the prescribing clinician based on the patient’s condition, severity of symptoms, and other medical factors. Exact dosing regimens are not provided here.

Safety data for Metopimazine during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metopimazine belongs to the phenothiazine class and primarily blocks dopamine receptors, whereas agents like ondansetron target serotonin (5‑HT3) receptors. The choice depends on the clinical scenario, patient tolerance, and potential drug‑specific side‑effect profiles.

Store Metopimazine tablets at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Metopimazine is taken orally as a tablet, usually with a glass of water. It can be administered with or without food, but patients should follow the specific instructions given by their prescriber.

Serious adverse reactions include extrapyramidal symptoms such as dystonia or akathisia, neuroleptic malignant syndrome, severe hypotension, and cardiac arrhythmias. Prompt medical attention is required if any of these events occur.

Metopimazine is contraindicated in individuals with known hypersensitivity to phenothiazine derivatives, in patients with severe Parkinsonian symptoms, and in those with uncontrolled cardiovascular disease where dopamine blockade could worsen the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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