Metopirone 250mg (Metyrapone Capsule) 250mg

Metyrapone works by inhibiting the enzyme 11-beta-hydroxylase, which is crucial for the synthesis of cortisol from 11-deoxycortisol in the adrenal cortex. This inhibition leads to a decrease in cortisol levels, which in turn increases the secretion of adrenocorticotropic hormone (ACTH) due to the loss of negative feedback on the pituitary gland.

The dosage of Metopirone is determined by a healthcare provider based on the patient's weight and specific medical condition. Typically, a single dose of 30 mg/kg is administered at midnight with food to reduce gastrointestinal irritation.

Metopirone is classified as Pregnancy Category C, meaning it should be used during pregnancy only if clearly needed. The potential benefits must be weighed against the potential risks to the fetus. Always consult a healthcare provider before use.

To order Metopirone from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will reply with pricing, availability, shipping details, and the necessary import paperwork.

Metopirone is specifically used for diagnostic testing of adrenal and pituitary function by inhibiting cortisol synthesis. It is different from other drugs like cosyntropin, which is used to stimulate cortisol production. The choice of drug depends on the specific diagnostic needs.

Metopirone should be stored below 25°C, in the original pack, and protected from moisture. Ensure the capsules are kept in a cool, dry place away from direct sunlight and out of reach of children.

Metopirone is administered orally, typically as a single dose of 30 mg/kg at midnight with food to reduce gastrointestinal irritation. The dose is usually given with yogurt or milk to enhance absorption.

The most serious risks associated with Metopirone include acute adrenal insufficiency, hypotension, and severe gastrointestinal irritation. Patients should be monitored closely for signs of adrenal crisis, and prophylactic cortisone acetate may be administered to prevent adverse effects.

Metopirone should not be used by patients with known adrenal insufficiency or those who are hypersensitive to metyrapone. It should be used with caution in pregnant women and those with severe liver or kidney disease. Always consult a healthcare provider before use.