Product image of Metopirone (Metyrapone) supplied by GNH India

Metopirone

Active Ingredient:
Metyrapone
Origin:
EU

Metopirone (Metyrapone)

Metyrapone, the active ingredient in Metopirone, is a steroidogenesis inhibitor presented as an oral formulation for oral use. It is used in the diagnostic testing of adrenal insufficiency and in the treatment of Cushing's syndrome in adults.

GNH India supplies Metopirone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hra Pharma Rare Diseases

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Indications & Clinical Uses

  • Metopirone acts on adrenal steroidogenesis and is employed in specific endocrine conditions.
  • Diagnostic testing of adrenal insufficiency: helps assess cortisol production capacity during ACTH stimulation.
  • Cushing's syndrome: reduces excess cortisol synthesis to improve clinical signs.
  • Adrenal function testing: used to evaluate the integrity of the hypothalamic‑pituitary‑adrenal axis.

How It Works

  • Metyrapone selectively inhibits the enzyme 11‑beta‑hydroxylase in the adrenal cortex, blocking the final step of cortisol biosynthesis. By preventing conversion of 11‑deoxycortisol to cortisol, it lowers circulating cortisol levels and allows clinicians to assess adrenal reserve or treat cortisol‑excess states.

Side Effects

Metyrapone may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or headache
  • Fatigue or mild abdominal discomfort
  • Transient hypertension
  • Mild hypokalemia

Serious or Rare Side Effects

  • Acute adrenal insufficiency
  • Severe hypertension or hypertensive crisis
  • Significant electrolyte disturbances (e.g., severe hypokalemia)
  • Allergic reactions including rash or anaphylaxis
  • Elevated liver enzymes or hepatic dysfunction

Precautions & Warnings

  • Before initiating Metopirone, several safety considerations should be reviewed.
  • Dose adjustment: monitor cortisol levels and adjust dosage as clinically indicated.
  • Pregnancy: safety not established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown excretion; weigh maternal benefit against possible infant exposure.
  • Concomitant glucocorticoids: may mask signs of adrenal insufficiency.
  • Drug interactions: review all concurrent medications for potential interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metyrapone can interact with several drugs that affect steroid metabolism or adrenal function.

Major Interactions (Avoid)

  • Ketoconazole: additive inhibition of steroidogenesis may cause severe adrenal suppression.
  • Glucocorticoids administered concurrently: may mask adrenal insufficiency symptoms.
  • Rifampin: induces hepatic enzymes, potentially reducing metyrapone efficacy.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: enzyme induction may lower drug levels.
  • Phenobarbital: may decrease therapeutic effect through increased metabolism.

Frequently Asked Questions

Metopirone (generic name metyrapone) is employed primarily for diagnostic testing of adrenal insufficiency and for the medical management of Cushing's syndrome, where it helps lower excess cortisol production.

Metyrapone inhibits the enzyme 11‑beta‑hydroxylase in the adrenal cortex, blocking the final step of cortisol synthesis. This reduction in cortisol allows clinicians to assess adrenal reserve or treat conditions of cortisol excess.

The dosage of Metopirone is individualized. A qualified prescriber determines the appropriate amount and schedule based on the patient’s clinical condition, laboratory results, and response to therapy.

Safety data for metyrapone in pregnancy and lactation are limited. It should only be used when the potential benefit outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Metopirone, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metopirone differs from other agents such as ketoconazole or osilodrostat by specifically targeting 11‑beta‑hydroxylase. It is often used when rapid cortisol reduction is needed or when other drugs are contraindicated, but individual response and side‑effect profiles guide therapy choice.

Metopirone should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain stability.

Metopirone is taken orally, usually as a tablet, with or without food as directed by the prescribing clinician. The exact timing and frequency depend on the therapeutic goal and patient monitoring.

Serious risks include acute adrenal insufficiency, severe hypertension, significant electrolyte disturbances such as hypokalemia, and rare allergic reactions. Patients should be monitored closely for these events, especially during dose adjustments.

Metopirone is contraindicated in patients with known hypersensitivity to metyrapone or any excipients, and should be used with caution in individuals with uncontrolled hypertension, severe liver disease, or those receiving high‑dose glucocorticoids without adequate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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