Product image of Metopocor (Metoprolol Tartrate) supplied by GNH India

Metopocor

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metopocor (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metopocor, is a beta blocker presented as an intravenous solution for intravenous use. It treats hypertension, angina pectoris, acute myocardial infarction and cardiac arrhythmias in adult patients.

GNH India supplies Metopocor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Metopocor, a selective β1‑adrenergic blocker, is used in several cardiovascular conditions.

  • Hypertension: lowers blood pressure by reducing heart rate and myocardial contractility.
  • Angina pectoris: relieves chest pain by decreasing myocardial oxygen demand.
  • Acute myocardial infarction: improves survival by reducing cardiac workload.
  • Cardiac arrhythmias: helps control heart rhythm by slowing conduction through the atrioventricular node.

How It Works

  • Metoprolol tartrate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, inhibiting the effects of endogenous catecholamines. This reduces heart rate, myocardial contractility, and renin release, leading to decreased cardiac output and lower systemic blood pressure, while also diminishing myocardial oxygen consumption.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Fatigue
  • Dizziness or light‑headedness
  • Bradycardia
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with reactive airway disease
  • Allergic reactions (rash, angioedema, anaphylaxis)
  • Depression or mood changes
  • Cardiogenic shock in susceptible individuals

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Dose adjustment in renal impairment: reduce dose as needed based on renal function.
  • Monitor heart rate: avoid excessive bradycardia, especially in patients with pre‑existing conduction disorders.
  • Use with caution in asthma or chronic obstructive pulmonary disease: may exacerbate bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension or tachycardia.
  • Pregnancy and lactation: safety not established; use only if clearly needed and prescribed by a specialist.
  • Store at below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Metopocor can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other beta blockers: risk of severe bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): may cause heart block or profound bradycardia.
  • Clonidine: abrupt withdrawal while on Metopocor can precipitate severe hypertension.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • Non‑selective beta blockers: additive blood pressure‑lowering effect.
  • NSAIDs: may reduce antihypertensive efficacy.
  • Antidepressants (SSRIs, SNRIs): potential increase in bradycardia risk.

Frequently Asked Questions

Metopocor contains metoprolol tartrate, a selective β1‑adrenergic blocker indicated for the management of hypertension, angina pectoris, acute myocardial infarction, and certain cardiac arrhythmias. It is employed in adult patients to lower blood pressure, reduce chest pain, improve post‑infarction outcomes, and help control abnormal heart rhythms.

Metoprolol tartrate blocks β1‑adrenergic receptors in the heart, diminishing the effects of adrenaline and noradrenaline. This leads to a slower heart rate, reduced contractile force, and lower renin release, collectively decreasing cardiac output and systemic blood pressure while also lowering myocardial oxygen demand.

The appropriate dose of Metopocor is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, response to therapy, and any comorbidities. Dosing regimens are not standardized in public literature and should follow the prescribing information provided by the healthcare professional.

Safety data for metoprolol tartrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician. Breastfeeding mothers should consult their doctor before using the product.

To request Metopocor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metopocor (metoprolol tartrate) is a cardio‑selective β1‑blocker, offering a more targeted effect on heart rate and contractility compared with non‑selective agents such as propranolol. This selectivity generally results in fewer respiratory side effects, making it a preferred option for patients with coexisting pulmonary disease, while still providing effective blood pressure and anti‑anginal control.

Metopocor should be stored at temperatures below 25 °C, in its original packaging, protected from light and moisture. The product must be kept out of reach of children and handled according to standard aseptic techniques for intravenous solutions to maintain sterility until administration.

Metopocor is supplied as an intravenous solution and is administered by slow IV injection or infusion under the supervision of a qualified healthcare professional. The exact rate and duration of administration are determined by the prescriber based on the clinical indication and patient response.

Serious adverse events include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions such as anaphylaxis. Patients should be monitored for signs of these conditions, especially during dose initiation or when combined with other medications that affect cardiac conduction.

Metopocor is contraindicated in patients with known hypersensitivity to metoprolol or any excipients, those with severe bradycardia (heart rate < 45 bpm), second‑ or third‑degree atrioventricular block without a pacemaker, cardiogenic shock, and in individuals with uncompensated heart failure. Caution is also advised for patients with severe asthma or chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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