Product image of Metopran (Metoclopramide Hydrochloride) supplied by GNH India

Metopran

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metopran (Metoclopramide Hydrochloride)

Metoclopramide Hydrochloride, the active ingredient in Metopran, is a dopamine antagonist / antiemetic presented as an oral dosage form for oral use. It is used to treat nausea, vomiting, gastroparesis and gastro‑oesophageal reflux disease in adults.

GNH India supplies Metopran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jadran-Galenski Laboratorij D.D.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Metoclopramide acts on the central chemoreceptor trigger zone and gastrointestinal motility to relieve symptoms in several disorders.

  • Nausea and vomiting: reduces the frequency and severity of episodes in patients with acute, postoperative or chemotherapy‑induced nausea.
  • Gastroparesis: enhances gastric emptying and improves related digestive discomfort.
  • Gastro‑oesophageal reflux disease (GERD): alleviates reflux symptoms by promoting gastric clearance.

How It Works

  • Metoclopramide Hydrochloride antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing nausea signals, while also blocking 5‑HT3 receptors. Peripheral actions include stimulation of acetylcholine release in the gastrointestinal tract, which increases smooth‑muscle contractility and accelerates gastric emptying, thereby improving motility.

Side Effects

Metopran may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Fatigue: general tiredness.
  • Restlessness: inner sense of unease or agitation.
  • Diarrhea: loose, watery stools.

Serious or Rare Side Effects

  • Extrapyramidal reactions: involuntary muscle movements such as dystonia.
  • Tardive dyskinesia: persistent, often irreversible facial or tongue movements.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Depression or suicidal thoughts: mood changes that may require immediate medical attention.

Precautions & Warnings

Before prescribing Metopran, clinicians should consider several safety aspects.

  • Assess renal and hepatic function: dose adjustment may be required in impairment.
  • Use the lowest effective dose: minimizes risk of extrapyramidal symptoms.
  • Monitor for movement disorders: watch for early signs of dystonia or tardive dyskinesia.
  • Avoid in patients with known hypersensitivity to metoclopramide or other dopamine antagonists.
  • Caution in pregnancy: benefits must outweigh potential risks.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metopran can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticholinergic agents: may increase constipation and reduce gastrointestinal motility.
  • CNS depressants (e.g., opioids, benzodiazepines): can enhance sedation and respiratory depression.
  • MAO inhibitors: may potentiate central nervous system effects.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): metoclopramide may alter their plasma concentrations.
  • Antidepressants (SSRIs, SNRIs): combined use can raise the risk of serotonin syndrome.

Frequently Asked Questions

Metopran, containing metoclopramide hydrochloride, is prescribed for nausea and vomiting of various origins, for gastroparesis to improve stomach emptying, and for gastro‑oesophageal reflux disease to reduce reflux symptoms by enhancing gastrointestinal motility.

Metoclopramide works by blocking dopamine D2 receptors in the brain’s chemoreceptor trigger zone, which reduces nausea signals, and by antagonizing 5‑HT3 receptors. Peripherally, it stimulates acetylcholine release in the gut, increasing smooth‑muscle contractions and accelerating gastric emptying.

The appropriate dose of Metopran is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for metoclopramide in pregnancy are limited, and the drug is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult a healthcare professional before use.

To order Metopran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metopran (metoclopramide) differs from many antiemetics by also acting as a gastro‑prokinetic, enhancing gastric motility. Compared with agents such as ondansetron, which primarily block serotonin receptors, metoclopramide adds dopamine antagonism and pro‑kinetic effects, making it useful for both nausea and delayed gastric emptying.

Metopran should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Metopran is taken orally, usually as a tablet or oral solution, with or without food as directed by the prescriber. The exact route of administration and timing depend on the specific indication and the clinician’s guidance.

Serious risks include extrapyramidal reactions such as dystonia, tardive dyskinesia, neuroleptic malignant syndrome, severe depression or suicidal thoughts, and rare cardiac arrhythmias. Patients should be monitored closely for any of these symptoms, and treatment should be stopped if they occur.

Metopran is contraindicated in individuals with known hypersensitivity to metoclopramide or other dopamine antagonists, in patients with pheochromocytoma, and in those with a history of severe extrapyramidal reactions. Caution is also advised for patients with gastrointestinal obstruction or perforation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metoclopramide Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT