Product image of Metoprolin (Metoprolol Tartrate) supplied by GNH India

Metoprolin

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolin (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolin, is a beta‑blocker presented as an oral tablet for oral use. It treats high blood pressure, chest pain, and certain heart rhythm disorders in adult patients.
GNH India supplies Metoprolin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Metoprolin is a beta‑blocker indicated for several cardiovascular conditions.

  • Hypertension: lowers blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival by limiting cardiac workload.
  • Chronic heart failure: enhances ventricular function and reduces symptoms.
  • Rate control in atrial fibrillation: slows ventricular response to maintain a regular rhythm.

How It Works

  • Metoprolol Tartrate selectively antagonizes β1‑adrenergic receptors in the heart, leading to reduced cyclic AMP formation. This decreases heart rate, myocardial contractility, and renin release, thereby lowering cardiac output and blood pressure while improving ventricular efficiency.

Side Effects

Metoprolin may cause a range of adverse reactions.

Common Side Effects

  • Fatigue: feeling unusually tired or weak.
  • Dizziness: light‑headedness, especially when standing quickly.
  • Bradycardia: slower than normal heart rate.
  • Cold extremities: hands or feet feel cool.
  • Gastrointestinal upset: nausea, abdominal discomfort.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slow heart rate requiring medical attention.
  • Heart block: impaired electrical conduction in the heart.
  • Hypotension: dangerously low blood pressure.
  • Bronchospasm: narrowing of airways, especially in asthmatic patients.
  • Depression: mood changes or worsening depression.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before starting Metoprolin, certain precautions should be considered.

  • Monitor blood pressure: check regularly during therapy.
  • Assess heart rate: watch for excessive bradycardia.
  • Caution in asthma/COPD: may exacerbate bronchospasm.
  • Use with caution in diabetes: may mask hypoglycemia symptoms.
  • Avoid abrupt discontinuation: taper under medical supervision.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metoprolin can interact with other medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive cardiac depression.
  • Calcium channel blockers (verapamil, diltiazem): risk of severe bradycardia.
  • Clonidine: may cause rebound hypertension if stopped.
  • Insulin or oral hypoglycemics: mask hypoglycemia signs.
  • Potassium‑sparing diuretics: increase risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive effect.
  • Thyroid hormones: may alter heart rate response.
  • Antidepressants (SSRIs): potential for additive bradycardia.
  • CYP2D6 inhibitors (e.g., fluoxetine): increase metoprolol levels.
  • Alcohol: may enhance hypotensive effect.

Frequently Asked Questions

Metoprolin, containing metoprolol tartrate, is prescribed for high blood pressure, chest pain due to angina, post‑myocardial infarction care, chronic heart failure, and for controlling heart rate in atrial fibrillation. These indications reflect its role as a selective β1‑blocker that reduces cardiac workload.

Metoprolol Tartrate works by selectively blocking β1‑adrenergic receptors in the heart. This inhibition reduces cyclic AMP formation, leading to slower heart rate, decreased contractile force, and lower renin release, which together lower blood pressure and lessen the heart's oxygen demand.

The exact dose of Metoprolin is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Healthcare providers adjust the amount and frequency to achieve therapeutic goals while monitoring for efficacy and safety.

Safety data for Metoprolin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Metoprolin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolin (metoprolol tartrate) is a β1‑selective blocker, offering cardiac effects with less impact on bronchial β2 receptors compared with non‑selective agents. This selectivity can make it preferable for patients with respiratory conditions, while still providing effective blood‑pressure and anti‑anginal control.

Metoprolin should be stored at ambient temperature below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Metoprolin is taken orally as a tablet. It should be swallowed whole with a glass of water, and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing, or signs of an allergic response.

Metoprolin is contraindicated in patients with severe bradycardia, second‑ or third‑degree atrioventricular block, uncompensated heart failure, severe asthma or chronic obstructive pulmonary disease, and in those with known hypersensitivity to metoprolol or any excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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