Product image of Metoprolol Al (Metoprolol Tartrate) supplied by GNH India

Metoprolol Al

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Al (Metoprolol Tartrate)

Metoprolol tartrate, the active ingredient in Metoprolol Al, is a beta‑adrenergic blocker presented as an oral tablet for oral use. It lowers blood pressure, relieves angina, and improves outcomes after myocardial infarction and in chronic heart failure. It is indicated for the management of hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure and selected cardiac arrhythmias, and is prescribed by physicians based on individual patient needs.

GNH India supplies Metoprolol Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Metoprolol Al, a selective β1‑adrenergic blocker, is used in several cardiovascular conditions.

  • Hypertension: reduces systolic and diastolic pressure by decreasing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival and reduces risk of recurrent events.
  • Chronic heart failure: enhances left‑ventricular function and reduces hospitalization.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other tachyarrhythmias.

How It Works

  • Metoprolol tartrate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, diminishing sympathetic stimulation. This leads to a slower heart rate, reduced myocardial contractility, and lower cardiac output, which together decrease arterial pressure and myocardial oxygen consumption, helping to control hypertension, angina, and heart failure.

Side Effects

Metoprolol Al may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fatigue
  • Dizziness
  • Bradycardia
  • Cold extremities
  • Gastrointestinal upset
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia
  • Heart block
  • Bronchospasm
  • Hypotension
  • Allergic reactions
  • Depression

Precautions & Warnings

When prescribing Metoprolol Al, clinicians should observe several safety considerations.

  • Monitor blood pressure: ensure target levels are achieved without excessive hypotension.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Use caution in asthma or chronic obstructive pulmonary disease: β1 selectivity may still affect bronchial tone.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension or tachycardia.
  • Adjust dose in renal impairment: reduced clearance may increase drug exposure.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metoprolol Al can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective beta blockers (e.g., propranolol): additive β‑blockade may cause profound bradycardia.
  • Calcium channel blockers verapamil or diltiazem: combined effect on cardiac conduction can lead to heart block.
  • Clonidine: concurrent use may precipitate severe hypertension if clonidine is withdrawn abruptly.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive effect.
  • Diuretics: can increase risk of electrolyte imbalance and hypotension.
  • NSAIDs: may reduce antihypertensive efficacy of metoprolol.

Frequently Asked Questions

Metoprolol Al is prescribed for several cardiovascular indications, including hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It helps control blood pressure, reduce chest pain, improve heart‑pump function, and stabilize abnormal heart rhythms.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart, reducing the effects of adrenaline and noradrenaline. This slows the heart rate, lowers myocardial contractility, and decreases cardiac output, which together lower arterial pressure and reduce the heart’s oxygen demand.

The appropriate dose of Metoprolol Al is individualized by the prescribing clinician based on the specific condition being treated, the patient’s age, weight, renal function, and response to therapy. Dosage adjustments are made to achieve therapeutic goals while minimizing side effects.

The pregnancy safety category for Metoprolol Al is not definitively established. Clinicians weigh potential benefits against possible risks before prescribing to pregnant or nursing women. If treatment is considered essential, close monitoring and consultation with obstetric specialists are recommended.

To order Metoprolol Al, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol Al is a selective β1‑blocker with a relatively short half‑life, often requiring twice‑daily dosing, whereas atenolol has a longer half‑life and is usually taken once daily. Both reduce heart rate and blood pressure, but metoprolol may provide more consistent control of angina and post‑MI outcomes, while atenolol is sometimes preferred for its dosing convenience.

Metoprolol Al should be stored below 25 °C in a dry place. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Metoprolol Al is taken orally as a tablet. It can be swallowed with or without food, but patients should follow the prescribing physician’s instructions regarding timing and whether the dose should be taken with meals to improve tolerability.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, severe dizziness, difficulty breathing, or signs of an allergic response.

Metoprolol Al is contraindicated in patients with known hypersensitivity to metoprolol or other beta‑blockers, those with severe bradycardia (heart rate < 45 bpm), second‑ or third‑degree atrioventricular block without a pacemaker, and individuals in cardiogenic shock. Caution is also advised for patients with uncontrolled asthma or severe peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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