Product image of Metoprolol Aurobindo (Metoprolol Tartrate) supplied by GNH India

Metoprolol Aurobindo

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Aurobindo (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Aurobindo, is a beta blocker presented as a tablet for oral use. It treats hypertension, angina pectoris, myocardial infarction, heart failure and certain arrhythmias in adult patients.

GNH India supplies Metoprolol Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

  • Metoprolol Tartrate is used to manage cardiovascular conditions that involve excessive sympathetic stimulation.
  • Hypertension: lowers blood pressure by reducing cardiac output and inhibiting renin release.
  • Angina pectoris: decreases myocardial oxygen demand by slowing heart rate and contractility.
  • Myocardial infarction: reduces risk of recurrent ischemic events through heart‑rate control.
  • Heart failure: improves survival by decreasing ventricular workload.
  • Arrhythmias: stabilises abnormal heart rhythms by blocking β1‑adrenergic receptors.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, diminishing the effects of endogenous catecholamines. This results in reduced heart rate, decreased myocardial contractility, and lowered conduction velocity through the AV node, ultimately decreasing cardiac output and oxygen demand.

Side Effects

Metoprolol Tartrate may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Headache
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal discomfort)

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma or COPD
  • Allergic reactions (rash, angioedema, anaphylaxis)
  • Depression or mood changes
  • Worsening heart failure symptoms

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for adverse events.
  • Assess cardiovascular status: confirm indication and baseline heart rate/blood pressure.
  • Monitor heart rate and blood pressure regularly during dose titration.
  • Use caution in patients with asthma, COPD, or other bronchospastic disease.
  • Adjust dose in renal or hepatic impairment as needed.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound tachycardia.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Metoprolol Tartrate can interact with several drug classes; careful review is essential.

Major Interactions (Avoid)

  • Concomitant AV‑nodal blockers (e.g., verapamil, diltiazem): may cause profound bradycardia.
  • Clonidine withdrawal: can precipitate severe hypertension.
  • Insulin or oral hypoglycemics: may mask hypoglycaemia symptoms.
  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): increase metoprolol plasma levels.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive efficacy.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance negative chronotropic effect.
  • Diuretics: can potentiate hypotensive response.
  • Antidepressants (SSRIs, SNRIs): may require blood pressure monitoring.
  • Anesthetic agents: may increase risk of intra‑operative bradycardia.
  • Potassium‑sparing diuretics: monitor serum potassium and cardiac rhythm.

Frequently Asked Questions

Metoprolol Aurobindo, containing metoprolol tartrate, is prescribed for hypertension, angina pectoris, post‑myocardial infarction management, chronic heart failure, and certain cardiac arrhythmias. It works by lowering heart rate and reducing the heart’s workload, helping to control blood pressure and improve cardiac efficiency.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart. By inhibiting the action of adrenaline and noradrenaline at these sites, it slows the heart rate, reduces contractile force, and decreases conduction through the AV node, which together lower cardiac output and oxygen demand.

The appropriate dose of Metoprolol Aurobindo is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage adjustments are made during treatment to achieve the desired therapeutic effect while minimizing side effects.

The safety of metoprolol tartrate in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Metoprolol Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metoprolol tartrate is a cardio‑selective (β1‑selective) beta blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its pharmacokinetic profile provides reliable heart‑rate control, making it a common choice for hypertension, angina, and heart‑failure management, whereas other beta blockers may be preferred for different comorbidities.

Metoprolol Aurobindo tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity.

Metoprolol Aurobindo is taken orally, usually with or without food, as directed by the prescribing clinician. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as anaphylaxis. Patients should be monitored for these events, especially during dose initiation or when combined with other cardiac‑active medications.

Metoprolol Aurobindo is contraindicated in patients with known hypersensitivity to metoprolol or any excipients, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals experiencing cardiogenic shock. Caution is also advised for patients with uncontrolled asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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