Product image of Metoprolol Carinopharm (Metoprolol Tartrate) supplied by GNH India

Metoprolol Carinopharm

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Carinopharm (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Carinopharm, is a beta blocker presented as an injectable solution for intravenous use. It treats hypertension, angina pectoris, acute myocardial infarction and cardiac arrhythmias in adult patients, helping to lower heart rate and myocardial oxygen demand.\n\nGNH India supplies Metoprolol Carinopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Carinopharm Gmbh

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Indications & Clinical Uses

  • Metoprolol Carinopharm, a selective β1‑adrenergic blocker, is used in cardiovascular conditions where reduction of heart rate and myocardial oxygen demand is desired.\n\nHypertension: lowers blood pressure by decreasing cardiac output.\nAngina pectoris: reduces frequency of chest‑pain episodes by lowering myocardial oxygen consumption.\nAcute myocardial infarction: improves survival by limiting cardiac workload and arrhythmias.\nCardiac arrhythmias: controls ventricular rate in atrial fibrillation and other supraventricular tachyarrhythmias.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in the heart, inhibiting catecholamine‑induced stimulation of adenylate cyclase. This reduces intracellular cyclic AMP, leading to decreased calcium influx, slower sino‑atrial node firing, reduced myocardial contractility, and lower cardiac output, thereby diminishing heart rate and blood pressure.

Side Effects

  • Common Side Effects:\n- Fatigue or weakness\n- Dizziness or light‑headedness\n- Bradycardia (slow heart rate)\n- Cold extremities\n- Headache\n- Gastrointestinal upset (nausea, abdominal discomfort)\n\nSerious or Rare Side Effects:\n- Severe bradycardia or heart block\n- Marked hypotension\n- Acute heart failure exacerbation\n- Bronchospasm, especially in patients with asthma or COPD\n- Allergic reactions including rash, angioedema or anaphylaxis\n- Cardiogenic shock in high‑risk patients

Precautions & Warnings

  • Metoprolol Carinopharm should be used with careful clinical monitoring in patients with existing cardiac conduction disorders.\n\nCardiovascular monitoring: observe heart rate and blood pressure during initiation and dose adjustments.\nRenal or hepatic impairment: consider dose reduction and monitor drug levels.\nAbrupt discontinuation: taper gradually to avoid rebound hypertension or tachycardia.\nRespiratory caution: use with caution in patients with asthma or chronic obstructive pulmonary disease.\nDiabetes management: monitor blood glucose as β‑blockade may mask hypoglycaemic symptoms.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Metoprolol Carinopharm may interact with several cardiovascular agents.\n\nMajor Interactions (Avoid):\n- Co‑administration with verapamil or diltiazem can cause profound bradycardia and AV‑block.\n- Concurrent use of other β‑blockers may lead to excessive β‑blockade.\n- Combination with clonidine may precipitate severe rebound hypertension on abrupt withdrawal.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs may enhance hypotensive effects.\n- Diuretics can increase the risk of orthostatic hypotension.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs) may reduce antihypertensive efficacy.

Frequently Asked Questions

Metoprolol Carinopharm is indicated for the management of hypertension, angina pectoris, acute myocardial infarction and various cardiac arrhythmias. It works by lowering heart rate and myocardial oxygen demand, helping to control blood pressure and reduce chest‑pain episodes.

Metoprolol Tartrate is a selective β1‑adrenergic receptor antagonist. By blocking these receptors in the heart, it reduces the effects of adrenaline, leading to decreased heart rate, contractility, and cardiac output, which in turn lowers blood pressure and myocardial oxygen consumption.

The appropriate dose of Metoprolol Carinopharm is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and any relevant comorbidities. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety of Metoprolol Carinopharm in pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Metoprolol Carinopharm is a cardio‑selective β1‑blocker, offering a favorable profile for patients where bronchial β2 blockade is undesirable. Compared with non‑selective beta blockers, it provides similar antihypertensive and anti‑anginal effects with reduced risk of bronchospasm, making it a preferred choice in patients with respiratory concerns.

Metoprolol Carinopharm should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Maintaining the cold‑chain ensures the stability and potency of the injectable solution.

Metoprolol Carinopharm is supplied as an injectable solution for intravenous use. It is administered by a healthcare professional, typically as a slow IV infusion or bolus, according to the prescriber’s dosing instructions and patient monitoring protocols.

Serious risks include severe bradycardia, heart block, marked hypotension, acute heart failure exacerbation, bronchospasm in susceptible individuals, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for these events, especially during dose initiation or escalation.

Metoprolol Carinopharm is contraindicated in patients with known hypersensitivity to metoprolol or any component of the formulation, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and patients in cardiogenic shock. Caution is also advised for individuals with uncontrolled asthma or severe peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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