Product image of Metoprolol Carinopharm (Metoprolol Tartrate) supplied by GNH India

Metoprolol Carinopharm

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Carinopharm (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Carinopharm, is a beta blocker presented as an injection for intravenous use. It treats hypertension, angina pectoris, acute myocardial infarction, heart failure and cardiac arrhythmias in adult patients.

GNH India supplies Metoprolol Carinopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Carinopharm Gmbh

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Indications & Clinical Uses

  • Metoprolol Carinopharm is a selective β1‑adrenergic antagonist used in cardiovascular conditions that require rate control or reduced myocardial workload.
  • Hypertension: lowers systemic blood pressure by decreasing cardiac output.
  • Angina pectoris: reduces myocardial oxygen demand, relieving chest pain.
  • Acute myocardial infarction: improves survival and limits infarct size.
  • Heart failure: decreases heart rate and improves ventricular filling.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other supraventricular tachyarrhythmias.

How It Works

  • Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, inhibiting catecholamine‑mediated stimulation. This reduces heart rate, myocardial contractility, and conduction velocity, leading to lower cardiac output and decreased oxygen consumption, which underlies its antihypertensive, anti‑anginal, and antiarrhythmic effects.

Side Effects

Metoprolol Carinopharm may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue or weakness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Headache
  • Nausea or mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma
  • Allergic reactions such as rash or angioedema
  • Cardiogenic shock or acute heart failure exacerbation

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: check regularly to avoid excessive hypotension.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Evaluate respiratory status: avoid in severe asthma or COPD where bronchospasm risk is high.
  • Review concomitant medications: be cautious with other AV‑node blockers or calcium channel blockers.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Metoprolol can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Verapamil or diltiazem: combined use may cause profound AV block.
  • Other β‑blockers: additive bradycardia and hypotension.
  • Clonidine abrupt withdrawal: may precipitate severe hypertension.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive efficacy.
  • Diuretics: risk of electrolyte disturbances and enhanced hypotensive effect.
  • Digoxin: may increase serum levels and risk of toxicity.
  • Selective serotonin reuptake inhibitors: can augment bradycardia.

Frequently Asked Questions

Metoprolol Carinopharm is indicated for the management of hypertension, angina pectoris, acute myocardial infarction, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It works by slowing the heart rate and reducing the force of contraction, which helps lower blood pressure and myocardial oxygen demand.

Metoprolol Tartrate is a selective β1‑adrenergic receptor antagonist. By blocking these receptors in the heart, it reduces sympathetic stimulation, leading to a slower heart rate, decreased contractility, and lower cardiac output. This results in reduced blood pressure and myocardial oxygen consumption, providing therapeutic benefit in cardiovascular disease.

The dosage of Metoprolol Carinopharm is individualized by the prescribing clinician based on the specific indication, patient characteristics, and response to therapy. Healthcare professionals determine the appropriate infusion rate and total daily amount according to clinical guidelines and patient monitoring.

The safety of Metoprolol Carinopharm in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. After verification, the sales team provides pricing, availability, shipping details (including cold‑chain handling if needed), and assists with import documentation.

Metoprolol is a cardio‑selective (β1‑selective) blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its intravenous formulation allows rapid titration in acute settings, whereas some alternatives are only available orally. Choice of beta blocker depends on the clinical scenario, comorbidities, and physician preference.

Metoprolol Carinopharm should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. Do not store at room temperature for extended periods, as stability may be compromised.

Metoprolol Carinopharm is administered intravenously. The injection is given as a slow infusion or bolus, according to the prescribing clinician’s instructions. Administration should occur in a setting where cardiac monitoring is available, allowing rapid adjustment based on heart rate and blood pressure responses.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible patients, and rare cases of cardiogenic shock. Prompt recognition and management are essential; clinicians should monitor cardiac rhythm, blood pressure, and respiratory status throughout therapy.

Metoprolol Carinopharm is contraindicated in patients with known hypersensitivity to metoprolol or any excipients, those with severe bradycardia (heart rate < 45 bpm), second‑ or third‑degree AV block without a pacemaker, cardiogenic shock, and uncontrolled severe asthma or COPD where β‑blockade may precipitate bronchospasm.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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