Product image of Metoprolol Pharmaclan (Metoprolol Tartrate) supplied by GNH India

Metoprolol Pharmaclan

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Pharmaclan (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Pharmaclan, is a beta‑adrenergic receptor blocker presented as a tablet formulation for oral use. It treats hypertension, angina pectoris, post‑myocardial infarction, chronic heart failure and cardiac arrhythmias in adult patients.

GNH India supplies Metoprolol Pharmaclan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmaclan S.R.O.

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Indications & Clinical Uses

Metoprolol Pharmaclan is a beta‑blocker used in several cardiovascular conditions.

  • Hypertension: lowers blood pressure by reducing cardiac output and renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival by limiting arrhythmias and remodeling.
  • Chronic heart failure: reduces mortality and hospitalisation through heart‑rate control.
  • Cardiac arrhythmias: stabilises rhythm by slowing conduction through the AV node.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, leading to decreased heart rate, reduced myocardial contractility and lower cardiac output. This results in diminished systemic blood pressure and reduced myocardial oxygen consumption, addressing the pathophysiology of hypertension, angina and certain arrhythmias.

Side Effects

Metoprolol Pharmaclan may cause a range of adverse reactions.

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness.
  • Bradycardia (slow heart rate).
  • Cold extremities.
  • Headache.
  • Mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe bradycardia or heart block.
  • Marked hypotension.
  • Bronchospasm, especially in patients with asthma or COPD.
  • Allergic reactions such as rash or angioedema.
  • Depression or mood changes.
  • Worsening heart failure.

Precautions & Warnings

Before initiating Metoprolol Pharmaclan, consider the following safety measures.

  • Monitor blood pressure: check regularly during dose titration.
  • Assess heart rate: avoid use in patients with resting bradycardia.
  • Caution in asthma/COPD: may exacerbate bronchospasm.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Metoprolol Pharmaclan can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia.
  • Calcium‑channel blockers (verapamil, diltiazem): risk of severe AV block.
  • Clonidine: abrupt withdrawal may cause rebound hypertension.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance hypotensive effect.
  • Diuretics: increase risk of electrolyte imbalance.
  • Antidiabetic agents: may mask hypoglycaemia symptoms.
  • Antidepressants (SSRIs): possible increase in plasma metoprolol levels.

Frequently Asked Questions

Metoprolol Pharmaclan is prescribed for hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure and certain cardiac arrhythmias. It works by lowering heart rate and blood pressure, which helps reduce the workload on the heart and improves oxygen supply to the myocardium.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart. This inhibition reduces heart‑rate, myocardial contractility and cardiac output, leading to lower blood pressure and decreased oxygen demand by the heart muscle, which is beneficial in treating the listed cardiovascular conditions.

The appropriate dose of Metoprolol Pharmaclan is determined by the prescribing healthcare professional based on the patient’s specific condition, response to therapy and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Metoprolol Pharmaclan in pregnancy or while breastfeeding has not been definitively established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing individuals. Patients should discuss their situation with a qualified clinician.

To order Metoprolol Pharmaclan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol Pharmaclan is a selective β1‑blocker, offering cardiac‑specific effects with fewer respiratory side‑effects compared with non‑selective beta‑blockers. Compared with agents like atenolol, metoprolol has a shorter half‑life and may require twice‑daily dosing, but both share similar efficacy in lowering blood pressure and heart rate.

Metoprolol Pharmaclan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Metoprolol Pharmaclan is taken orally, usually with or without food as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe bradycardia, marked hypotension, heart block, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing or swelling of the face or throat.

Metoprolol Pharmaclan is contraindicated in patients with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, overt heart failure decompensation, and those with known hypersensitivity to metoprolol or any excipients. Caution is also advised for individuals with asthma, COPD, or uncontrolled diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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