Product image of Metoprolol Retard Stada (Metoprolol Tartrate) supplied by GNH India

Metoprolol Retard Stada

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Retard Stada (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Retard Stada, is a beta‑blocker presented as an oral tablet for oral use. It is employed to lower blood pressure, relieve angina, and improve outcomes after myocardial infarction and in chronic heart failure.
GNH India supplies Metoprolol Retard Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

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Indications & Clinical Uses

  • Metoprolol Retard Stada is a selective β1‑blocker used in several cardiovascular conditions.
  • Hypertension: lowers systolic and diastolic pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival by limiting arrhythmias and remodeling.
  • Chronic heart failure: enhances ventricular function and reduces hospitalization risk.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other tachyarrhythmias.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting catecholamine‑induced stimulation of adenylate cyclase. This reduces intracellular cAMP, leading to decreased calcium influx, slower sino‑atrial node firing, reduced myocardial contractility, and lower cardiac output, ultimately lowering blood pressure and myocardial oxygen consumption.

Side Effects

Metoprolol Retard Stada may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal pain)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm in patients with reactive airway disease
  • Depression or mood changes
  • Allergic reactions (rash, angioedema)
  • Worsening heart failure in susceptible individuals

Precautions & Warnings

  • Before prescribing Metoprolol Retard Stada, clinicians should assess patient‑specific factors and monitor for potential complications.
  • Cardiovascular assessment: evaluate baseline heart rate and blood pressure.
  • Respiratory caution: avoid in patients with severe asthma or COPD without specialist advice.
  • Diabetes monitoring: watch for masked hypoglycaemia symptoms.
  • Concomitant drugs: review other rate‑controlling agents for additive effects.
  • Gradual withdrawal: taper dose to prevent rebound hypertension or tachycardia.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metoprolol Retard Stada can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Verapamil or diltiazem: risk of severe bradycardia and AV block.
  • Clonidine abrupt discontinuation: may cause rebound hypertension.
  • Other antihypertensives (e.g., ACE inhibitors, diuretics): additive hypotensive effect.
  • Insulin or oral hypoglycaemic agents: may mask hypoglycaemia signs.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive response.
  • Diuretics: can enhance hypotensive effect, requiring dose adjustment.

Frequently Asked Questions

Metoprolol Retard Stada is prescribed for high blood pressure, chronic stable angina, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It works by slowing the heart rate and reducing the force of contraction, which helps to lower blood pressure and myocardial oxygen demand.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart. This inhibition reduces the effects of adrenaline and noradrenaline, leading to a slower heart rate, decreased contractility, and lower cardiac output, which together help control blood pressure and relieve angina.

The appropriate dose of Metoprolol Retard Stada is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage adjustments may be needed for specific patient groups, and the regimen should always follow the prescriber’s instructions.

Safety data for Metoprolol Retard Stada in pregnancy and lactation are limited, and the product’s pregnancy category is not definitively established. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metoprolol Retard Stada is a selective β1‑blocker, offering cardiac‑focused effects with fewer respiratory side effects compared with non‑selective agents like propranolol. Its extended‑release formulation provides once‑daily dosing, which can improve adherence relative to immediate‑release beta‑blockers that require multiple daily doses.

Store Metoprolol Retard Stada at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Metoprolol Retard Stada is taken orally, usually once daily with or without food, as directed by the prescriber. The tablet should be swallowed whole and not split, crushed, or chewed to maintain the extended‑release properties.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and worsening heart failure. Patients should be monitored for these events, especially during dose initiation or when combined with other rate‑controlling drugs.

Metoprolol Retard Stada is contraindicated in patients with known hypersensitivity to metoprolol or other beta‑blockers, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals with uncompensated heart failure or severe asthma/COPD unless specifically advised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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