Metoprolol Retard Teva (Metoprolol Tartrate)

Metoprolol Retard Teva is a selective β1‑adrenergic blocker indicated for several cardiovascular conditions.

• Hypertension: reduces systolic and diastolic blood pressure to target levels.
• Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
• Post‑myocardial infarction: lowers the risk of recurrent infarction and improves survival.
• Chronic heart failure: improves left‑ventricular function and reduces hospitalisation.

• Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, diminishing sympathetic stimulation. This reduces heart rate, myocardial contractility, and cardiac output, which together lower arterial pressure and myocardial oxygen consumption, helping to control hypertension, angina, and heart‑failure progression.

Metoprolol Retard Teva may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

• Fatigue or tiredness
• Dizziness, especially on standing
• Cold extremities
• Gastrointestinal upset (nausea, abdominal discomfort)
• Bradycardia (slow heart rate)
• Mild sleep disturbances

Serious or Rare Side Effects

• Severe bradycardia or heart block
• Acute heart failure exacerbation
• Bronchospasm in patients with asthma or COPD
• Hypotensive crisis
• Allergic reactions (rash, angioedema)

Before prescribing Metoprolol Retard Teva, clinicians should assess cardiovascular status and comorbid conditions.

• Cardiac conduction disorders: avoid or monitor closely in patients with AV block.
• Severe asthma or chronic obstructive pulmonary disease: use with caution due to possible bronchoconstriction.
• Diabetes mellitus: monitor blood glucose as β‑blockade may mask hypoglycaemia symptoms.
• Pregnancy and lactation: prescribe only if potential benefit justifies potential risk.
• Drug discontinuation: taper gradually to prevent rebound hypertension or tachycardia.
• Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and light.

Metoprolol Retard Teva can interact with several medicines that affect heart rate, blood pressure, or drug metabolism.

Major Interactions (Avoid)

• Non‑selective β‑blockers or other negative chronotropes (e.g., verapamil, diltiazem) – risk of profound bradycardia.
• Strong CYP2D6 inhibitors (e.g., paroxetine, quinidine) – may increase metoprolol plasma levels.

Moderate Interactions (Monitor Closely)

• Antidiabetic agents – β‑blockade may mask hypoglycaemia signs.
• Diuretics – may potentiate hypotensive effect.
• NSAIDs – can reduce antihypertensive efficacy.
• Antidepressants (e.g., SSRIs) – monitor for additive bradycardia.