Product image of Metoprolol Slavia (Metoprolol Tartrate) supplied by GNH India

Metoprolol Slavia

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Slavia (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Slavia, is a selective β1‑adrenergic receptor blocker presented as an oral tablet for oral administration. It is indicated for the management of hypertension, angina pectoris, myocardial infarction, heart failure, and certain cardiac arrhythmias in adult patients.

GNH India supplies Metoprolol Slavia as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide from its EU‑sourced manufacturing network. The company adheres to stringent quality standards and offers reliable logistics for global distribution.

Manufacturer / TM Owner

Slavia Pharm Srl

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Indications & Clinical Uses

Metoprolol Slavia is a beta‑blocker that acts on the cardiovascular system to control blood pressure and heart workload.

  • Hypertension: lowers systemic blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Myocardial infarction: improves survival after an acute heart attack by limiting cardiac workload.
  • Heart failure: reduces ventricular remodeling and improves functional capacity.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, leading to a reduction in heart rate, myocardial contractility, and renin release. The resulting decrease in cardiac output and sympathetic stimulation lowers arterial pressure and myocardial oxygen consumption, providing therapeutic benefit in hypertension, angina, and various cardiac disorders.

Side Effects

Metoprolol Slavia may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness.
  • Bradycardia (slow heart rate).
  • Cold extremities.
  • Headache.
  • Gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe bradycardia or heart block.
  • Marked hypotension.
  • Bronchospasm, especially in patients with asthma.
  • Acute heart failure exacerbation.
  • Allergic reactions such as rash or angioedema.
  • Depression or mood changes.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Monitor blood pressure: ensure adequate control without excessive hypotension.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Use caution in asthma or chronic obstructive pulmonary disease: β1‑selectivity may not fully prevent bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension or tachycardia.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metoprolol Slavia can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective beta blockers: additive bradycardia.
  • Calcium‑channel blockers (verapamil, diltiazem): risk of severe bradycardia and AV block.
  • Clonidine: abrupt withdrawal may cause hypertensive crisis.
  • Insulin or oral hypoglycemics: may mask hypoglycaemia symptoms.
  • MAO inhibitors: potential for exaggerated hypotensive response.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance hypotensive effect.
  • Diuretics: risk of excessive blood pressure reduction.
  • Antidepressants (SSRIs, SNRIs): possible additive effects on heart rate.

Frequently Asked Questions

Metoprolol Slavia is prescribed for hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias. It works by lowering heart rate and blood pressure, thereby reducing the workload on the heart.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart. This inhibition reduces heart rate, myocardial contractility, and renin release, leading to lower cardiac output and blood pressure, which helps control hypertension and relieve chest pain.

The appropriate dose of Metoprolol Slavia is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments are made individually and should follow the prescriber’s instructions.

The safety of Metoprolol Slavia in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Metoprolol Slavia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metoprolol Slavia is a β1‑selective blocker, offering cardiac‑focused effects with less impact on bronchial β2 receptors compared with non‑selective agents. This selectivity can make it preferable for patients with respiratory concerns, while still providing effective blood‑pressure and anti‑anginal control.

Metoprolol Slavia should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat to maintain product stability.

Metoprolol Slavia is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions. Patients should be monitored for these events, especially when initiating therapy or adjusting the dose.

Metoprolol Slavia is contraindicated in patients with known hypersensitivity to metoprolol or other β‑blockers, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals in cardiogenic shock. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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