Product image of Metoprolol Tartrate Accord Healthcare (Metoprolol Tartrate) supplied by GNH India

Metoprolol Tartrate Accord Healthcare

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Tartrate Accord Healthcare (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Tartrate Accord Healthcare, is a beta blocker presented as an oral tablet for oral use. It lowers blood pressure, relieves angina, and helps control heart rhythm in adults with cardiovascular conditions.

GNH India supplies Metoprolol Tartrate Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured bulk shipments and regulatory compliance across multiple markets. The company leverages a robust distribution network to meet demand in both developed and emerging healthcare systems.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Metoprolol Tartrate is a selective β1‑adrenergic blocker used in cardiovascular disease management.

  • Hypertension: reduces systolic and diastolic pressure to target levels.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Myocardial infarction: improves survival by limiting cardiac workload after an acute event.
  • Heart failure: lowers heart rate and contractility to improve ventricular filling and reduce symptoms.
  • Cardiac arrhythmias: stabilises abnormal heart rhythms by slowing conduction through the AV node.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, leading to decreased heart rate, reduced myocardial contractility, and lower cardiac output. This results in diminished renin release from the kidneys and a subsequent fall in systemic blood pressure, while also lowering myocardial oxygen consumption during stress.

Side Effects

Metoprolol Tartrate may be associated with a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness, especially on standing.
  • Cold extremities such as hands and feet.
  • Nausea or mild gastrointestinal upset.

Serious or Rare Side Effects

  • Bradycardia (abnormally slow heart rate).
  • Symptomatic hypotension (low blood pressure).
  • AV block or other serious cardiac conduction disturbances.
  • Bronchospasm in patients with reactive airway disease.
  • Severe allergic reactions including rash, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Metoprolol Tartrate, clinicians should evaluate the patient's overall cardiovascular status and monitor for potential complications.

  • Assess cardiovascular status before initiating: obtain baseline blood pressure and heart rate.
  • Monitor for signs of heart‑failure exacerbation: watch for peripheral edema, sudden weight gain, or dyspnoea.
  • Use caution in patients with asthma or COPD: β‑blockade may provoke bronchospasm.
  • Avoid abrupt discontinuation: taper the dose to prevent rebound hypertension or tachycardia.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Metoprolol Tartrate can interact with several drug classes, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Verapamil or diltiazem: combined use may cause severe bradycardia or AV block.
  • Clonidine: abrupt withdrawal of clonidine while on Metoprolol can precipitate hypertensive crisis.
  • Non‑selective β‑blockers: concurrent use increases risk of excessive β‑blockade.

Moderate Interactions (Monitor Closely)

  • Diuretics (especially thiazides): may potentiate hypotensive effects; monitor electrolytes.
  • NSAIDs: can reduce antihypertensive efficacy of Metoprolol.
  • Antidiabetic agents (insulin, sulfonylureas): Metoprolol may mask hypoglycaemia symptoms; adjust glucose monitoring.

Frequently Asked Questions

Metoprolol Tartrate Accord Healthcare is prescribed for several cardiovascular conditions, including hypertension, angina pectoris, post‑myocardial infarction management, chronic heart failure, and certain cardiac arrhythmias. It works by lowering heart rate and blood pressure, thereby reducing the workload on the heart.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart. This inhibition reduces heart rate, myocardial contractility, and cardiac output, leading to lower blood pressure and decreased oxygen demand by the heart muscle. The drug also diminishes renin release from the kidneys, contributing to its antihypertensive effect.

The appropriate dose of Metoprolol Tartrate Accord Healthcare is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosage instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of Metoprolol Tartrate during pregnancy or lactation has not been definitively established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing women. Patients should discuss any concerns with their physician before starting or continuing therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol Tartrate is a cardio‑selective (β1‑selective) blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its relatively short half‑life allows flexible dosing, but may require multiple daily doses. Clinicians choose it when selective β1 blockade is desired, especially in patients with respiratory concerns.

Metoprolol Tartrate Accord Healthcare should be stored at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct sunlight, and ensure the packaging remains tightly closed until use.

Metoprolol Tartrate is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions given by their prescriber to maintain consistent blood levels and therapeutic effect.

Serious risks include marked bradycardia, symptomatic hypotension, atrioventricular block, and bronchospasm in patients with reactive airway disease. Rarely, severe allergic reactions such as anaphylaxis can occur. Patients should seek immediate medical attention if they experience fainting, severe dizziness, difficulty breathing, or swelling of the face or throat.

Metoprolol Tartrate should be avoided in individuals with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree AV block without a pacemaker, decompensated heart failure, or uncontrolled asthma/COPD. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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