Product image of Metoprolol Tartrate Bristol Laboratories (Metoprolol Tartrate Ph. Eur.) supplied by GNH India

Metoprolol Tartrate Bristol Laboratories

Active Ingredient:
Metoprolol Tartrate Ph. Eur.
Origin:
EU

Metoprolol Tartrate Bristol Laboratories (Metoprolol Tartrate Ph. Eur.)

Metoprolol tartrate, the active ingredient in Metoprolol Tartrate Bristol Laboratories, is a beta blocker presented as an oral tablet for oral use. It is indicated for hypertension, angina pectoris, post‑myocardial infarction management, heart failure and selected cardiac arrhythmias in adult patients.

GNH India supplies Metoprolol Tartrate Bristol Laboratories as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmacopeial standards and is manufactured under GMP conditions. It is distributed to a broad network of healthcare providers across Europe, Asia and the Americas.

Manufacturer / TM Owner

Bristol Laboratories Limited

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Indications & Clinical Uses

  • Metoprolol tartrate is a selective β1‑adrenergic blocker used in cardiovascular conditions.
  • Hypertension: lowers blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival and reduces risk of recurrent events.
  • Heart failure: lowers ventricular workload and improves symptoms in chronic heart failure.
  • Cardiac arrhythmias: controls heart rate in certain supraventricular tachyarrhythmias.

How It Works

  • Metoprolol tartrate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, blocking the action of endogenous catecholamines such as norepinephrine. This inhibition reduces intracellular cyclic AMP, leading to decreased calcium influx, slower sino‑atrial node firing, reduced myocardial contractility, and a lower heart rate, collectively diminishing cardiac output and arterial pressure.

Side Effects

Metoprolol tartrate may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue: feeling of tiredness or lack of energy.
  • Dizziness: light‑headedness, especially on standing.
  • Bradycardia: slower than normal heart rate.
  • Cold extremities: reduced blood flow to hands and feet.
  • Gastrointestinal upset: nausea or abdominal discomfort.
  • Sleep disturbances: insomnia or vivid dreams.

Serious or Rare Side Effects

  • Severe bradycardia: markedly low heart rate requiring medical attention.
  • Heart block: impairment of electrical conduction.
  • Hypotension: dangerously low blood pressure.
  • Bronchospasm: worsening of asthma or COPD symptoms.
  • Heart failure exacerbation: worsening of existing heart failure.
  • Depression or mood changes: new or worsening depressive symptoms.

Precautions & Warnings

When prescribing metoprolol tartrate, clinicians should consider several precautionary measures to ensure safe use.

  • Dose adjustment in renal impairment: reduce dose in patients with reduced kidney function.
  • Caution in asthma or COPD: monitor for bronchospasm due to β‑blockade.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound tachycardia or hypertension.
  • Monitor heart rate and blood pressure: assess regularly during therapy.
  • Use with caution in diabetes: may mask hypoglycaemia symptoms.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Metoprolol tartrate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: concurrent use may cause excessive β‑blockade.
  • Calcium channel blockers (verapamil, diltiazem): increase metoprolol plasma levels, risk of bradycardia.
  • Antidiabetic agents (insulin, sulfonylureas): may enhance hypoglycaemia risk.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, diuretics): additive blood pressure lowering.
  • Antidepressants (SSRIs, MAO inhibitors): may affect heart rate control.
  • NSAIDs: may reduce antihypertensive effect.
  • Digoxin: may increase risk of bradyarrhythmias.

Frequently Asked Questions

Metoprolol Tartrate Bristol Laboratories is prescribed for high blood pressure (hypertension), chest pain due to angina pectoris, management after a myocardial infarction, chronic heart failure, and certain cardiac arrhythmias where heart‑rate control is needed.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart, reducing the effects of adrenaline and noradrenaline. This leads to a slower heart rate, decreased contractile force, and lower cardiac output, which together help lower blood pressure and reduce the heart’s oxygen demand.

The appropriate dose of metoprolol tartrate is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any other concurrent medications. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for metoprolol tartrate in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol is a cardio‑selective (β1‑selective) blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its pharmacokinetic profile provides once‑ or twice‑daily dosing options, making it a common choice for hypertension, angina and post‑MI therapy.

Metoprolol Tartrate Bristol Laboratories should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Metoprolol tartrate is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber to maintain consistent blood levels.

Serious adverse events include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and worsening heart‑failure symptoms. Patients should seek immediate medical attention if they experience fainting, severe dizziness, or difficulty breathing.

Metoprolol tartrate is contraindicated in patients with known hypersensitivity to the drug, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncompensated heart failure. Clinicians should also exercise caution in patients with asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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