Product image of Metoprolol Z Hexal (Metoprolol Tartrate) supplied by GNH India

Metoprolol Z Hexal

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Z Hexal (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Z Hexal, is a beta‑blocker presented as an oral dosage form for oral use. It is employed to lower blood pressure, relieve angina pectoris, manage heart rhythm disorders, and improve outcomes after myocardial infarction.

GNH India supplies Metoprolol Z Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with adherence to stringent quality standards.

Manufacturer / TM Owner

Sandoz Hungária Kft

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Indications & Clinical Uses

Metoprolol Z Hexal, a selective β1‑adrenergic blocker, is used in several cardiovascular conditions.

  • Hypertension: reduces systolic and diastolic blood pressure by decreasing cardiac output.
  • Angina pectoris: alleviates chest pain by lowering myocardial oxygen demand.
  • Acute myocardial infarction: improves survival by reducing cardiac workload and arrhythmias.
  • Heart failure: enhances left‑ventricular function and lowers risk of hospitalization.
  • Cardiac arrhythmias: controls heart rate and stabilises abnormal rhythms.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, blocking catecholamine‑stimulated adenylate cyclase activity. This lowers intracellular cyclic AMP, reduces calcium influx, and consequently decreases heart rate, myocardial contractility, and cardiac output, while sparing β2 receptors and minimising bronchial effects.

Side Effects

Metoprolol Z Hexal may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue: feeling of tiredness.
  • Dizziness: light‑headedness on standing.
  • Bradycardia: slower heart rate.
  • Gastrointestinal upset: nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe bradycardia: dangerously low heart rate.
  • Heart block: impaired cardiac conduction.
  • Hypotension: markedly low blood pressure.
  • Bronchospasm: airway constriction, especially in patients with asthma.

Precautions & Warnings

When prescribing Metoprolol Z Hexal, clinicians should consider several precautionary measures to ensure safe use.

  • Assess cardiac function: evaluate heart rate and blood pressure before initiation.
  • Review respiratory history: use cautiously in patients with asthma or COPD.
  • Monitor glucose: beta‑blockers may mask hypoglycaemia symptoms in diabetic patients.
  • Adjust for renal/hepatic impairment: dose may need modification in severe dysfunction.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound tachycardia or hypertension.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Metoprolol Z Hexal can interact with other medicines, altering its effectiveness or increasing risk of adverse events.

Major Interactions (Avoid)

  • Calcium channel blockers (verapamil, diltiazem): increase risk of severe bradycardia and hypotension.
  • CYP2D6 inhibitors (paroxetine, quinidine): elevate metoprolol concentrations.
  • Antidiabetic agents (insulin, sulfonylureas): may mask hypoglycaemia symptoms.

Moderate Interactions (Monitor Closely)

  • NSAIDs (ibuprofen, naproxen): can diminish blood‑pressure‑lowering effect.
  • Other beta‑blockers: additive cardiac depression.
  • Thyroid hormone therapy (levothyroxine): may require dose adjustment of metoprolol.

Frequently Asked Questions

Metoprolol Z Hexal contains metoprolol tartrate, a selective β1‑blocker indicated for the treatment of hypertension, chronic stable angina, acute myocardial infarction, heart failure, and certain cardiac arrhythmias. It works by lowering heart rate and cardiac output, thereby reducing blood pressure and myocardial oxygen demand.

Metoprolol Tartrate blocks β1‑adrenergic receptors in the heart, preventing catecholamines from stimulating the adenylate‑cyclase pathway. This reduces cyclic AMP levels, leading to decreased calcium influx, slower heart rate, reduced contractility, and lower cardiac output, which together help control blood pressure and relieve angina.

The appropriate dose of Metoprolol Z Hexal is determined by the prescribing healthcare professional based on the patient’s specific condition, response to therapy, and any comorbidities. Dosage regimens can vary widely, and the prescriber will tailor the amount and frequency to achieve optimal therapeutic effect.

Safety data for metoprolol during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Metoprolol Z Hexal. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Metoprolol is a cardio‑selective (β1‑specific) blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Compared with calcium‑channel blockers, metoprolol more directly reduces heart rate and myocardial oxygen demand, making it a preferred option for angina and certain arrhythmias, while individual patient factors guide final selection.

Metoprolol Z Hexal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Metoprolol Z Hexal is taken orally, usually with or without food as directed by the prescriber. Tablets should be swallowed whole with a full glass of water. The dosing schedule (once daily, twice daily, etc.) is individualized based on the therapeutic indication and patient response.

Serious adverse events include severe bradycardia, heart block, marked hypotension, and bronchospasm in patients with underlying respiratory disease. Patients should seek immediate medical attention if they experience fainting, unusually slow heartbeat, difficulty breathing, or chest pain while on therapy.

Metoprolol Z Hexal is contraindicated in patients with known hypersensitivity to metoprolol or any component of the formulation, those with severe sinus bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals in cardiogenic shock. Caution is also advised for patients with severe asthma or chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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