Product image of Metoprolol-Z Retard Al (Metoprolol Tartrate) supplied by GNH India

Metoprolol-Z Retard Al

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol-Z Retard Al (Metoprolol Tartrate)

Metoprolol tartrate, the active ingredient in Metoprolol‑Z Retard Al, is a beta‑adrenergic blocking agent presented as an oral tablet for oral use. It lowers blood pressure, relieves angina and supports heart‑failure management in adult patients.

GNH India supplies Metoprolol‑Z Retard Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Metoprolol tartrate is used to manage cardiovascular conditions that involve excessive sympathetic stimulation.

  • Hypertension: lowers systolic and diastolic pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain during exertion.
  • Post‑myocardial infarction: improves survival by limiting arrhythmias and remodeling.
  • Chronic heart failure: enhances ventricular function and reduces hospitalisation risk.
  • Certain cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other supraventricular tachyarrhythmias.

How It Works

  • Metoprolol tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting catecholamine‑induced stimulation. This reduces heart rate, myocardial contractility and conduction velocity, leading to decreased cardiac output and lower arterial pressure, while also diminishing myocardial oxygen consumption.

Side Effects

Metoprolol tartrate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Gastrointestinal discomfort such as nausea or abdominal pain

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm in patients with reactive airway disease
  • Allergic reactions including rash or angioedema
  • Depression or mood changes

Precautions & Warnings

Metoprolol tartrate requires careful monitoring in several clinical situations.

  • Monitor blood pressure: check regularly to avoid excessive hypotension.
  • Assess heart rate: ensure rate does not fall below safe limits.
  • Use caution in asthma or chronic obstructive pulmonary disease: β1‑selectivity may not fully prevent bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound tachycardia or hypertension.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Metoprolol tartrate can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): may cause severe heart block.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: may mask hypoglycaemia symptoms.
  • NSAIDs: can reduce antihypertensive effect.
  • Antidepressants (e.g., SSRIs): may increase plasma metoprolol levels.

Frequently Asked Questions

Metoprolol‑Z Retard Al contains metoprolol tartrate, a beta‑blocker indicated for hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It works by reducing heart rate and myocardial workload, helping to control blood pressure and relieve chest pain.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart. By inhibiting the effects of adrenaline and noradrenaline, it slows the heart rate, lowers contractile force, and reduces the speed of electrical conduction. These actions decrease cardiac output and arterial pressure, and lower the heart’s oxygen demand.

The appropriate dose of Metoprolol‑Z Retard Al is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any co‑existing health issues. Dosage adjustments may be required for renal impairment or elderly patients, and the regimen should always follow the prescriber’s instructions.

Safety data for metoprolol tartrate in pregnancy are limited, and the drug is generally classified as use‑only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so a healthcare professional should evaluate the risk‑benefit balance before use during lactation.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Metoprolol tartrate is a β1‑selective blocker, offering cardiac‑focused effects with less impact on bronchial β2 receptors compared with non‑selective agents like propranolol. This selectivity can make it preferable for patients with respiratory concerns, though individual response and tolerability vary, and choice of therapy should be guided by the treating physician.

Store Metoprolol‑Z Retard Al at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metoprolol‑Z Retard Al is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed, unless a specific formulation advises otherwise.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions such as angioedema. Patients should be monitored for these events, especially when initiating therapy or adjusting the dose.

Metoprolol‑Z Retard Al is contraindicated in patients with known hypersensitivity to metoprolol or other β‑blockers, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncompensated heart failure or cardiogenic shock. Caution is also advised for patients with severe asthma or chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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