Product image of Metoprolol Zentiva (Metoprolol Tartrate) supplied by GNH India

Metoprolol Zentiva

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Zentiva (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprolol Zentiva, is a beta blocker presented as an oral tablet for oral use. It lowers blood pressure and reduces cardiac workload in adults with hypertension, angina, or other cardiovascular conditions.

GNH India supplies Metoprolol Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable logistics for global distribution. Our network ensures timely delivery and regulatory support across multiple regions. We also offer technical assistance for product integration.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Metoprolol Zentiva is a selective β1‑adrenergic blocker used in several cardiovascular conditions.

  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain during exertion.
  • Heart failure: improves left ventricular function and reduces hospitalizations in chronic heart failure patients.
  • Post‑myocardial infarction prophylaxis: lowers risk of recurrent ischemic events and arrhythmias after an MI.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other supraventricular tachyarrhythmias.

How It Works

  • Metoprolol Tartrate selectively antagonizes β1‑adrenergic receptors located primarily in cardiac tissue. By blocking catecholamine binding, it reduces cyclic AMP formation, leading to decreased intracellular calcium, slower sino‑atrial node firing, reduced myocardial contractility, and lower heart rate. The resulting decline in cardiac output and renin release contributes to its antihypertensive and anti‑ischemic effects. Additionally, the β1‑selectivity minimizes bronchial smooth‑muscle impact, making it preferable in patients without severe asthma.

Side Effects

Metoprolol Zentiva may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm in susceptible individuals
  • Allergic reactions (rash, angioedema)
  • Depression or mood changes

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Cardiac assessment: evaluate baseline heart rate and rhythm.
  • Monitor blood pressure and heart rate regularly during treatment.
  • Caution in asthma or COPD: β1‑selectivity may still affect bronchial tone.
  • Dose adjustment: consider renal or hepatic impairment when titrating.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metoprolol Zentiva can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Other AV‑nodal blockers (e.g., verapamil, diltiazem) may cause excessive bradycardia.
  • Clonidine withdrawal can precipitate hypertensive crisis if metoprolol is stopped abruptly.
  • Insulin or oral hypoglycemics: metoprolol may mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can increase metoprolol plasma levels.
  • NSAIDs may reduce the antihypertensive effect of metoprolol.

Frequently Asked Questions

Metoprolol Zentiva is prescribed to manage hypertension, relieve angina pectoris, treat chronic heart failure, prevent recurrent events after a myocardial infarction, and control ventricular rate in certain cardiac arrhythmias such as atrial fibrillation.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, reducing the effects of adrenaline and noradrenaline. This leads to a slower heart rate, decreased contractility, lower cardiac output, and reduced renin release, which together lower blood pressure and myocardial oxygen demand.

The appropriate dose of Metoprolol Zentiva is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Metoprolol Zentiva in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Metoprolol Zentiva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metoprolol Zentiva is a β1‑selective blocker, offering cardiac‑focused effects with less impact on bronchial β2 receptors compared with non‑selective agents. This selectivity can make it preferable for patients without severe asthma, while still providing effective blood‑pressure and anti‑ischemic control similar to other cardio‑selective beta blockers.

Metoprolol Zentiva should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from excess moisture and direct sunlight to maintain its stability and potency.

Metoprolol Zentiva is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as fainting, extreme fatigue, difficulty breathing, or swelling of the face and throat.

Metoprolol Zentiva is contraindicated in patients with known hypersensitivity to metoprolol or any component of the formulation, in those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and in patients with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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