Product image of Metoprolol Zk Biofarm (Metoprolol Tartrate) supplied by GNH India

Metoprolol Zk Biofarm

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprolol Zk Biofarm (Metoprolol Tartrate)

Metoprolol, the active ingredient in Metoprolol Zk Biofarm, is a beta‑adrenergic blocker presented as a tablet oral for oral use. It treats hypertension, angina pectoris, myocardial infarction, heart failure and certain cardiac arrhythmias in adult patients.

GNH India supplies Metoprolol Zk Biofarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biofarm Sp. Z O.O.

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Indications & Clinical Uses

Metoprolol is a selective β1‑blocker used in cardiovascular disease management. It helps control blood pressure and heart workload across several conditions.

  • Hypertension: lowers systolic and diastolic pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Myocardial infarction: improves survival by limiting heart strain after an acute event.
  • Heart failure: enhances ventricular function and reduces hospitalization risk.
  • Cardiac arrhythmias: stabilises heart rhythm by slowing conduction through the AV node.

How It Works

  • Metoprolol selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting catecholamine‑induced stimulation of adenylate cyclase. This reduces intracellular cyclic AMP, leading to decreased calcium influx, slower sino‑atrial node firing, reduced myocardial contractility, and lower cardiac output, ultimately lowering blood pressure and heart rate.

Side Effects

Metoprolol may cause a range of adverse reactions, from mild to severe. Patients should be aware of both common and rare events.

Common Side Effects

  • Fatigue
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal pain)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in asthmatic patients
  • Acute heart failure exacerbation
  • Allergic reactions (rash, angioedema)
  • Depression or mood changes

Precautions & Warnings

Before initiating Metoprolol, clinicians should evaluate patient history and monitor for specific risks.

  • Monitor blood pressure: ensure values are within target range after starting therapy.
  • Assess cardiac function: watch for signs of worsening heart failure or conduction abnormalities.
  • Use caution in asthma or chronic obstructive pulmonary disease: β1‑selectivity may not fully prevent bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound tachycardia or hypertension.
  • Adjust dose in renal impairment: renal clearance may affect drug levels.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metoprolol can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Verapamil or diltiazem: combined AV‑node blockade may cause severe bradycardia.
  • Clonidine: abrupt withdrawal of clonidine while on Metoprolol can precipitate hypertensive crisis.
  • Other β‑blockers: additive cardiac depression may lead to heart block.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive effect.
  • Diuretics: risk of excessive hypotension or electrolyte imbalance.
  • Antidepressants (e.g., SSRIs, SNRIs): may increase plasma Metoprolol levels.
  • Calcium channel blockers (non‑dihydropyridines): require dose adjustment.
  • Antidiabetic agents: may mask hypoglycaemia symptoms.

Frequently Asked Questions

Metoprolol Zk Biofarm is prescribed for several cardiovascular conditions, including hypertension, angina pectoris, post‑myocardial infarction management, chronic heart failure, and certain cardiac arrhythmias. By lowering heart rate and reducing myocardial workload, it helps control blood pressure and improve cardiac efficiency in adult patients.

Metoprolol selectively blocks β1‑adrenergic receptors in the heart, preventing catecholamines such as adrenaline from stimulating these receptors. This inhibition reduces cyclic AMP formation, leading to slower heart‑node firing, decreased contractility, and lower cardiac output, which together lower blood pressure and heart rate.

The appropriate dose of Metoprolol Zk Biofarm is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors such as renal function. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of Metoprolol Zk Biofarm in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against possible risks before prescribing it to pregnant or nursing women. Patients should discuss their specific situation with a qualified professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol is a cardio‑selective (β1‑selective) blocker, which generally offers fewer respiratory side effects than non‑selective agents such as propranolol. Its pharmacokinetic profile allows once‑ or twice‑daily dosing, and it is widely used for hypertension and heart‑failure management, whereas some alternatives may be preferred for migraine prophylaxis or tremor control.

Metoprolol Zk Biofarm tablets should be stored at room temperature, below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metoprolol Zk Biofarm is administered orally, typically as a whole tablet swallowed with water. The exact dosing schedule—once daily or divided doses—depends on the indication and the prescriber’s recommendation. Patients should not crush or chew the tablet unless specifically instructed.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with obstructive airway disease, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, severe shortness of breath, or signs of an allergic response.

Metoprolol Zk Biofarm is contraindicated in patients with known hypersensitivity to metoprolol or any component of the formulation, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals experiencing cardiogenic shock. Caution is also advised for patients with uncontrolled asthma or severe peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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