Product image of Metoprololo Hexal (Metoprolol Tartrate) supplied by GNH India

Metoprololo Hexal

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprololo Hexal (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprololo Hexal, is a beta blocker presented as a tablet for oral use. It treats hypertension, angina, post‑myocardial infarction care, chronic heart failure and certain cardiac arrhythmias in adult patients. It is indicated for adult patients with elevated blood pressure, stable angina, after myocardial infarction, and for long‑term management of heart failure, helping to improve survival and reduce cardiovascular events.

GNH India supplies Metoprololo Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows Good Distribution Practice (GDP) standards, ensures product integrity through controlled shipping, and provides regulatory documentation to support import requirements across EU, Asia, Africa and the Americas.

Manufacturer / TM Owner

Sandoz S.P.A.

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Indications & Clinical Uses

  • Metoprolol Tartrate is a beta‑adrenergic blocker used in cardiovascular disease management.
  • Hypertension: lowers blood pressure by reducing cardiac output and inhibiting renin release.
  • Angina pectoris: relieves chest pain by decreasing myocardial oxygen demand through heart‑rate and contractility reduction.
  • Post‑myocardial infarction: improves survival and lowers risk of recurrent infarction by stabilising cardiac rhythm and limiting remodelling.
  • Chronic heart failure: enhances left‑ventricular function and reduces hospitalisation by controlling heart rate and neuro‑hormonal activation.
  • Cardiac arrhythmias: controls ventricular rate in atrial fibrillation and other supraventricular tachyarrhythmias.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors primarily located in cardiac tissue. By blocking catecholamine binding, it reduces heart rate, myocardial contractility, and conduction velocity, leading to decreased cardiac output. The drug also diminishes renin secretion from the kidneys, contributing to lower systemic vascular resistance. This combined effect results in reduced blood pressure and myocardial oxygen demand, supporting its use in hypertension, angina, post‑infarction care, heart failure and certain arrhythmias.

Side Effects

Metoprolol Tartrate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal discomfort (nausea, abdominal pain)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma
  • Acute heart‑failure exacerbation
  • Allergic reactions (rash, angioedema, anaphylaxis)
  • Depression or mood changes

Precautions & Warnings

  • Before prescribing Metoprolol Tartrate, clinicians should consider several safety precautions.
  • Assess cardiovascular status: evaluate baseline heart rate and blood pressure to avoid excessive bradycardia or hypotension.
  • Review respiratory history: use cautiously in patients with asthma or chronic obstructive pulmonary disease due to possible bronchospasm.
  • Monitor glucose control: beta‑blockade may mask hypoglycaemia symptoms in diabetic patients.
  • Avoid abrupt discontinuation: sudden cessation can precipitate rebound hypertension, tachycardia, or angina.
  • Consider renal/hepatic function: dose adjustments may be needed in severe impairment.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metoprolol Tartrate can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other β‑blockers or calcium‑channel blockers (verapamil, diltiazem) → additive bradycardia or AV block.
  • Anti‑arrhythmic agents (e.g., amiodarone, quinidine) → increased risk of conduction disturbances.
  • Clonidine withdrawal → severe rebound hypertension.
  • Insulin or oral hypoglycemics → mask hypoglycaemia signs.
  • Non‑selective β‑blockers → excessive β‑blockade.

Moderate Interactions (Monitor Closely)

  • NSAIDs (ibuprofen, naproxen) → may reduce antihypertensive effect.
  • Diuretics (thiazides, loop diuretics) → enhance hypotensive response.
  • Antidepressants (SSRIs, tricyclics) → potential for additive cardiac effects.
  • Antipsychotics (haloperidol, risperidone) → may increase QT prolongation risk.
  • CYP2D6 inhibitors (fluoxetine, paroxetine) → raise metoprolol plasma levels.

Frequently Asked Questions

Metoprololo Hexal contains metoprolol tartrate, a beta‑blocker indicated for hypertension, stable angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It is prescribed to adult patients to lower blood pressure, reduce chest‑pain episodes, improve survival after a heart attack, and support long‑term heart‑failure management.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart, preventing catecholamines from stimulating these receptors. This action slows the heart rate, reduces the force of contraction, and lowers cardiac output. It also suppresses renin release from the kidneys, decreasing systemic vascular resistance. The combined effects lower blood pressure and myocardial oxygen demand, which underpins its therapeutic use.

The exact dose of Metoprololo Hexal is individualized by the prescribing clinician based on the patient’s medical condition, severity, age, renal and hepatic function, and response to therapy. Dosage adjustments may be required for elderly patients or those with organ impairment. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

The safety of Metoprololo Hexal in pregnancy and lactation has not been definitively established, and the product is listed with an unknown pregnancy category. Healthcare providers must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatments or close monitoring with their physician.

To order Metoprololo Hexal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify institutional credentials, provide pricing, confirm availability, arrange shipping (including any required temperature control), and handle import documentation.

Metoprololo Hexal (metoprolol tartrate) is a selective β1‑blocker, offering cardiac‑specific effects with fewer respiratory side effects compared with non‑selective agents like propranolol. Compared with atenolol, metoprolol has a shorter half‑life and may require multiple daily doses, but it provides more consistent heart‑rate control. Choice of beta blocker depends on patient comorbidities, dosing convenience, and physician preference.

Metoprololo Hexal tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original blister pack or container, protect it from moisture, direct sunlight, and extreme heat. Do not store in the bathroom or near a kitchen sink. Proper storage helps maintain tablet potency throughout its shelf life.

Metoprololo Hexal is taken orally as a tablet. The tablet should be swallowed whole with a full glass of water, preferably at the same times each day to maintain steady blood levels. It can be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with asthma or COPD, and acute heart‑failure exacerbation. Rare but critical reactions such as allergic anaphylaxis, depression, or profound fatigue may also occur. Patients should seek immediate medical attention if they experience fainting, chest pain, severe shortness of breath, or signs of an allergic reaction.

Metoprololo Hexal is contraindicated in patients with severe bradycardia (heart rate < 45 bpm), second‑ or third‑degree atrioventricular block, cardiogenic shock, overt heart‑failure decompensation, or uncontrolled asthma/COPD where bronchospasm could be life‑threatening. It should also be avoided in individuals with known hypersensitivity to metoprolol or any excipients in the tablet formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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