Product image of Metoprololsuccinat Md (Metoprolol Tartrate) supplied by GNH India

Metoprololsuccinat Md

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprololsuccinat Md (Metoprolol Tartrate)

Metoprolol, the active ingredient in Metoprololsuccinat Md, is a beta blocker presented as an oral dosage form for oral use. It is employed to manage hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias in adult patients.

GNH India supplies Metoprololsuccinat Md as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Mylan Germany Gmbh

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Indications & Clinical Uses

Metoprolol is a selective β1‑adrenergic blocker used in several cardiovascular conditions.

  • Hypertension: lowers blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: reduces risk of recurrent ischemic events and improves survival.
  • Chronic heart failure: improves ventricular function and reduces hospitalisation.
  • Cardiac arrhythmias: helps control heart rate in atrial fibrillation and other rhythm disorders.

How It Works

  • Metoprolol selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting catecholamine‑induced stimulation of adenylate cyclase. This blockade diminishes intracellular cyclic AMP, leading to reduced calcium influx, slower sino‑atrial node firing, decreased myocardial contractility, and lower cardiac output, thereby lowering blood pressure and heart rate.

Side Effects

Metoprolol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fatigue: feeling of tiredness or lack of energy.
  • Dizziness: light‑headedness, especially on standing.
  • Bradycardia: slower than normal heart rate.
  • Cold extremities: reduced blood flow to hands and feet.
  • Gastrointestinal upset: nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe bradycardia: heart rate dropping to dangerously low levels.
  • Heart block: impairment of electrical conduction.
  • Hypotension: marked drop in blood pressure causing fainting.
  • Bronchospasm: tightening of airway muscles, especially in asthmatic patients.
  • Depression or mood changes: new or worsening depressive symptoms.

Precautions & Warnings

When prescribing Metoprolol, clinicians should consider several safety measures.

  • Assess cardiac function: evaluate heart rate and blood pressure before initiation.
  • Review respiratory history: avoid in patients with uncontrolled asthma or severe COPD.
  • Monitor glucose: beta‑blockers may mask hypoglycaemia symptoms in diabetics.
  • Adjust for renal/hepatic impairment: dose may need modification in reduced clearance.
  • Caution with concomitant AV‑node blockers: increased risk of bradyarrhythmias.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Metoprolol can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): increased risk of heart block.
  • Antidiabetic agents (insulin, sulfonylureas): may mask hypoglycaemia signs.
  • Clonidine withdrawal: abrupt discontinuation can cause rebound hypertension.
  • MAO inhibitors: heightened cardiovascular effects.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): may enhance bradycardia.
  • NSAIDs: can reduce antihypertensive effect.
  • Digoxin: increased serum levels leading to toxicity.
  • Diuretics: may potentiate hypotensive response.
  • Antihistamines: possible additive sedation.

Frequently Asked Questions

Metoprololsuccinat Md contains the beta‑blocker metoprolol and is indicated for the treatment of hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias such as atrial fibrillation. It helps control heart rate and lower blood pressure in these cardiovascular conditions.

Metoprolol works by selectively blocking β1‑adrenergic receptors in the heart. This reduces the effects of adrenaline and noradrenaline, leading to a slower heart rate, decreased myocardial contractility, and lower cardiac output, which together help lower blood pressure and relieve cardiac workload.

The appropriate dose of Metoprololsuccinat Md is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any co‑existing health issues. Dosage adjustments may be required for renal or hepatic impairment, and the prescriber will provide specific instructions.

Safety data for metoprolol in pregnancy are limited, and the drug should only be used if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so caution is advised for nursing mothers, and a healthcare professional should evaluate the risk‑benefit ratio.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Metoprololsuccinat Md. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol is a cardio‑selective (β1‑selective) beta blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Compared with calcium channel blockers, it provides stronger heart‑rate control but may be less effective for peripheral vasodilation. Choice of therapy depends on the patient’s overall cardiovascular profile and comorbidities.

Metoprololsuccinat Md should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Metoprololsuccinat Md is administered orally, usually as a tablet or capsule taken with or without food as directed by the prescriber. The exact dosing schedule (once daily, twice daily, etc.) is individualized based on the therapeutic indication and patient response.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and worsening heart failure. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, shortness of breath, or any signs of allergic reaction.

Metoprololsuccinat Md is contraindicated in patients with known hypersensitivity to metoprolol or other beta blockers, those with severe bradycardia (heart rate <50 bpm), second‑ or third‑degree atrioventricular block without a pacemaker, and individuals in cardiogenic shock. Caution is also advised for patients with uncontrolled asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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