Product image of Metoprololsuccinat Polpharma (Metoprolol Tartrate) supplied by GNH India

Metoprololsuccinat Polpharma

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprololsuccinat Polpharma (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprololsuccinat Polpharma, is a beta blocker presented as a tablet for oral use. It treats hypertension, angina pectoris, post‑myocardial infarction, chronic heart failure and certain cardiac arrhythmias in adult patients. The medication is indicated for long‑term management of cardiovascular disease and is administered under physician supervision.

GNH India supplies Metoprololsuccinat Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing regulated quality‑assured batches through established distribution networks and supporting timely delivery.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Metoprolol Tartrate is used to manage cardiovascular conditions that involve elevated blood pressure or cardiac workload.
  • Hypertension: lowers systemic blood pressure and reduces cardiovascular risk.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival and reduces recurrence of cardiac events.
  • Chronic heart failure: lowers mortality and hospitalisation rates.
  • Certain cardiac arrhythmias: controls heart rate and stabilises rhythm.

How It Works

  • Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, reducing sympathetic stimulation. This leads to decreased heart rate, myocardial contractility, and cardiac output, which together lower arterial pressure and diminish myocardial oxygen consumption.

Side Effects

Metoprolol Tartrate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities or peripheral circulation changes
  • Gastrointestinal upset such as nausea or abdominal discomfort
  • Sleep disturbances or vivid dreams

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma or COPD
  • Depression or significant mood changes
  • Allergic reactions including rash, angioedema, or anaphylaxis
  • Worsening heart failure or pulmonary edema

Precautions & Warnings

  • When prescribing Metoprolol Tartrate, clinicians should consider several safety measures.
  • Monitor blood pressure: check regularly to avoid excessive hypotension.
  • Assess heart rate: watch for bradycardia, especially in patients with conduction disorders.
  • Evaluate respiratory status: use cautiously in patients with asthma or COPD.
  • Review renal and hepatic function: dose may need adjustment in impairment.
  • Consider drug interactions: avoid concurrent use with other β‑blockers or certain calcium‑channel blockers.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Metoprolol Tartrate can interact with a variety of medicines, requiring careful management.

Major Interactions (Avoid)

  • Concomitant non‑selective β‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): risk of severe bradycardia and AV block.
  • Antidiabetic agents: may mask hypoglycaemia symptoms.
  • MAO inhibitors: can enhance bradycardic effect.
  • Clonidine abrupt withdrawal: may cause rebound hypertension.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may increase risk of hypotension.
  • Diuretics: enhance blood‑pressure‑lowering effect.
  • NSAIDs: may reduce antihypertensive efficacy.
  • Anticholinergic drugs: may increase risk of bronchospasm.
  • Digoxin: may raise serum digoxin levels.

Frequently Asked Questions

Metoprololsuccinat Polpharma contains metoprolol tartrate, a beta‑blocker indicated for hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias. It helps lower blood pressure, reduce chest‑pain episodes, improve survival after a heart attack, and control heart rate in rhythm disorders.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in cardiac tissue. By inhibiting sympathetic stimulation, it slows the heart rate, reduces the force of contraction, and lowers cardiac output, which together decrease arterial pressure and myocardial oxygen demand.

The appropriate dose of Metoprololsuccinat Polpharma is determined by the prescribing clinician based on the patient’s specific condition, response, and any comorbidities. Dosage adjustments may be required for renal or hepatic impairment, and the medication should be taken exactly as directed by a healthcare professional.

Safety data for metoprolol in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate individual circumstances before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol is a selective β1‑blocker, differing from ACE inhibitors, ARBs, calcium‑channel blockers, and diuretics in its mechanism of reducing heart rate and contractility. It is often chosen when heart rate control is needed, but may be combined with other classes for additive blood‑pressure reduction.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Metoprololsuccinat Polpharma is taken orally, usually with or without food, as directed by a physician. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing, or swelling of the face or throat.

Metoprolol is contraindicated in patients with known hypersensitivity to the drug, severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, cardiogenic shock, and uncontrolled heart failure. Caution is also advised for individuals with asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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