Product image of Metoprololtartraat Accord (Metoprolol Tartrate) supplied by GNH India

Metoprololtartraat Accord

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprololtartraat Accord (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metoprololtartraat Accord, is a beta blocker presented as various strengths/tablet for oral use. It treats hypertension, angina pectoris, heart failure, myocardial infarction prophylaxis and certain arrhythmias in adult patients. GNH India supplies Metoprololtartraat Accord as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Metoprololtartraat Accord is a cardio‑selective beta‑blocker used in several cardiovascular conditions.

  • Hypertension: lowers blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Heart failure: improves survival and reduces hospitalisations by lowering cardiac workload.
  • Myocardial infarction prophylaxis: reduces risk of recurrent infarction and mortality.
  • Arrhythmias: controls heart rate in supraventricular tachycardia and atrial fibrillation.

How It Works

  • Metoprolol Tartrate selectively antagonizes β1‑adrenergic receptors in cardiac tissue. By blocking catecholamine binding, it diminishes sinus node automaticity, slows atrioventricular conduction, and reduces myocardial contractility, leading to decreased heart rate, stroke volume, cardiac output and systemic blood pressure.

Side Effects

Metoprololtartraat Accord may cause a range of adverse reactions.

Common Side Effects

  • Fatigue: feeling of tiredness or lack of energy.
  • Dizziness: light‑headed sensation, especially on standing.
  • Bradycardia: slower than normal heart rate.
  • Cold extremities: reduced blood flow to hands and feet.
  • Gastrointestinal upset: nausea, abdominal discomfort.
  • Depression: mood changes or low mood.

Serious or Rare Side Effects

  • Severe bradycardia or heart block requiring medical attention.
  • Marked hypotension leading to fainting.
  • Bronchospasm in patients with reactive airway disease.
  • Worsening heart failure symptoms.
  • Allergic reactions such as rash or angioedema.
  • Cardiogenic shock in susceptible individuals.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood pressure: ensure adequate control without excessive hypotension.
  • Assess cardiac function: evaluate for existing heart block or severe bradycardia.
  • Review concomitant beta‑blockers: avoid additive effects.
  • Adjust dose in renal impairment: consider reduced clearance.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound tachycardia.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Metoprololtartraat Accord can interact with various medicines; some require avoidance while others need careful monitoring.

Major Interactions (Avoid)

  • Verapamil or diltiazem: may cause profound bradycardia or heart block.
  • Clonidine withdrawal: can precipitate severe hypertension.
  • Insulin or oral hypoglycemics: may mask hypoglycemia symptoms.
  • Non‑steroidal anti‑inflammatory drugs: can reduce antihypertensive efficacy.
  • Other antihypertensives: additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor renal function and potassium.
  • Diuretics: watch for excessive blood pressure drop.
  • Antidepressants (e.g., SSRIs): observe for heart rate changes.
  • Antidiabetic agents: adjust glucose monitoring.
  • Calcium channel blockers (non‑dihydropyridine): monitor cardiac conduction.

Frequently Asked Questions

Metoprololtartraat Accord is a beta‑blocker indicated for the management of hypertension, angina pectoris, chronic heart failure, post‑myocardial infarction prophylaxis and certain cardiac arrhythmias. It reduces heart rate and myocardial workload, helping to control blood pressure and improve cardiac efficiency. The prescribing clinician selects it based on the patient’s specific cardiovascular condition and treatment guidelines.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, preventing catecholamines from stimulating these receptors. This inhibition lowers sinus node firing, slows atrioventricular conduction, and reduces myocardial contractility. The overall effect is a decrease in heart rate, stroke volume, cardiac output, and systemic blood pressure, which lessens the heart’s oxygen demand.

The exact dose of Metoprololtartraat Accord is determined by the prescribing clinician based on the indication, disease severity, patient age, renal function and any concurrent medications. Typically, therapy starts at a low dose and may be titrated upward during follow‑up visits. Patients should follow the prescriber’s instructions and never adjust the dose on their own.

Safety data for Metoprolol Tartrate in pregnancy and lactation are limited. The drug is generally prescribed only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and alternative therapies with their healthcare provider before initiating treatment.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the inquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements) and the necessary import documentation.

Metoprolol Tartrate is a cardio‑selective β1‑blocker, offering fewer respiratory side effects than non‑selective agents such as propranolol, making it preferable for patients with asthma or chronic obstructive lung disease. Its efficacy in lowering blood pressure and heart rate is comparable to other selective blockers like atenolol. Choice of agent depends on individual comorbidities, tolerability and physician preference.

Metoprololtartraat Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or near heat sources. Do not use the medication after the expiry date printed on the label.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed. Consistency in the time of day helps maintain stable blood levels; patients should follow the dosing schedule provided on the prescription label.

Serious adverse reactions, although uncommon, include marked bradycardia, heart block, severe hypotension, bronchospasm in patients with reactive airway disease, and worsening heart failure. Patients should seek immediate medical attention if they experience fainting, chest pain, severe shortness of breath, or a rapid change in heart rhythm. Regular monitoring by a healthcare professional helps mitigate these risks.

Metoprololtartraat Accord is contraindicated in individuals with known hypersensitivity to metoprolol or any excipients, those with severe sinus bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, cardiogenic shock, or overt decompensated heart failure. Caution is also advised for patients with uncontrolled asthma or severe peripheral vascular disease. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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