Product image of Metoprololtartraat Sandoz (Metoprolol Tartrate) supplied by GNH India

Metoprololtartraat Sandoz

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metoprololtartraat Sandoz (Metoprolol Tartrate)

Metoprolol tartrate, the active ingredient in Metoprololtartraat Sandoz, is a beta blocker presented as a tablet for oral use. It is used to manage hypertension, angina pectoris, heart failure and certain cardiac arrhythmias in adult patients. It is indicated for patients requiring cardiovascular risk reduction and symptom control.

GNH India supplies Metoprololtartraat Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable supply chains across Europe, Asia and the Americas.

Manufacturer / TM Owner

Sandoz B.V.

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Indications & Clinical Uses

Metoprolol tartrate is a selective β1‑adrenergic blocker used in cardiovascular disease management.

  • Hypertension: lowers blood pressure by reducing heart rate and cardiac output.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Heart failure: improves survival and reduces hospitalizations by decreasing cardiac workload.
  • Cardiac arrhythmias: controls heart rate and stabilizes rhythm in supraventricular tachycardia.

How It Works

  • Metoprolol tartrate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, blocking the action of endogenous catecholamines such as norepinephrine and epinephrine. This inhibition reduces cyclic AMP formation, leading to decreased intracellular calcium, slower sino‑atrial node firing, reduced myocardial contractility, and lower renin release, collectively diminishing heart rate, contractile force and blood pressure.

Side Effects

Metoprolol tartrate may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Fatigue
  • Dizziness
  • Cold extremities
  • Bradycardia
  • Gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Hypotension unresponsive to treatment
  • Bronchospasm in patients with asthma
  • Depression or mood changes

Precautions & Warnings

When prescribing Metoprolol tartrate, clinicians should consider several safety measures.

  • Initiate therapy cautiously: start at low dose in patients with severe cardiac disease.
  • Monitor heart rate: avoid use if resting heart rate is below 50 bpm without supervision.
  • Assess renal and hepatic function: dose adjustments may be needed in impairment.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension or tachycardia.
  • Contraindications: do not use in patients with overt heart block, cardiogenic shock, or severe asthma.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and light.

Avoid Interactions

Metoprolol tartrate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Combined use with non‑selective β‑blockers or calcium channel blockers (verapamil/diltiazem): risk of profound bradycardia and AV block.
  • Concomitant administration with potent CYP2D6 inhibitors (e.g., quinidine, paroxetine): may markedly increase metoprolol plasma levels.

Moderate Interactions (Monitor Closely)

  • Concurrent use with antidiabetic agents: β‑blockade can mask hypoglycemia symptoms, requiring glucose monitoring.
  • Interaction with NSAIDs or selective COX‑2 inhibitors: may attenuate antihypertensive effect.
  • Use with inhaled β2‑agonists: may reduce bronchodilator response, monitor respiratory status.

Frequently Asked Questions

Metoprololtartraat Sandoz contains metoprolol tartrate, a beta‑blocker indicated for the treatment of hypertension, angina pectoris, chronic heart failure and certain cardiac arrhythmias such as supraventricular tachycardia. It helps lower blood pressure, reduce chest pain, improve heart‑failure outcomes and control abnormal heart rhythms.

Metoprolol tartrate selectively blocks β1‑adrenergic receptors in the heart, preventing norepinephrine and epinephrine from binding. This reduces cyclic AMP production, leading to lower intracellular calcium, slower pacemaker activity, decreased contractility and reduced renin release, which together lower heart rate, myocardial oxygen demand and blood pressure.

The appropriate dose of Metoprololtartraat Sandoz is determined by the prescribing clinician based on the individual’s medical condition, response to therapy and any comorbidities. Dosage may be adjusted over time, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for metoprolol tartrate in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case individually and discuss alternatives when appropriate.

To request Metoprololtartraat Sandoz, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol tartrate is a cardio‑selective (β1‑specific) blocker, offering a favorable profile for patients with respiratory conditions compared with non‑selective agents. Compared with agents like atenolol, metoprolol has a shorter half‑life, allowing more flexible dosing, while still providing effective blood‑pressure and heart‑rate control.

Metoprololtartraat Sandoz tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging, protect from moisture and light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Metoprololtartraat Sandoz is taken orally, usually with or without food, as directed by a healthcare professional. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious adverse events can include severe bradycardia, heart block, profound hypotension, bronchospasm in patients with asthma or chronic obstructive pulmonary disease, and worsening heart failure. Patients should be monitored for these signs, especially when initiating therapy or adjusting the dose.

Metoprololtartraat Sandoz is contraindicated in individuals with overt second‑ or third‑degree heart block, cardiogenic shock, severe bradycardia (resting heart rate <50 bpm) without supervision, and in patients with severe asthma or uncontrolled bronchospastic disease. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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