Product image of Metotab (Methotrexate) supplied by GNH India

Metotab

Active Ingredient:
Methotrexate
Origin:
EU

Metotab (Methotrexate)

Methotrexate, the active ingredient in Metotab, is a folate antagonist presented as an oral tablet for oral use. It is employed in the management of several autoimmune and oncologic conditions, including rheumatoid arthritis, psoriasis, and certain leukemias and lymphomas as well as related blood cancers.

GNH India supplies Metotab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. Our distribution network adheres to stringent quality standards and regulatory requirements across EU and global markets.

Manufacturer / TM Owner

Medac Sas

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Indications & Clinical Uses

Methotrexate is a folate antagonist used in autoimmune and oncologic disease management.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: diminishes skin lesions and plaque formation.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication.
  • Non‑Hodgkin lymphoma: impedes growth of lymphoma cells.
  • Ectopic pregnancy: terminates trophoblastic tissue in early implantation.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the synthesis of purine nucleotides and thymidylate, essential for DNA replication and cell division. The resulting antiproliferative effect targets rapidly dividing cells, including immune cells and malignant clones, providing both immunosuppressive and antineoplastic activity.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue and malaise.
  • Oral mucosal ulceration.
  • Elevated liver enzymes.
  • Transient leukopenia or neutropenia.
  • Diarrhea.

Serious or Rare Side Effects

  • Severe hepatotoxicity or fibrosis.
  • Pulmonary fibrosis or interstitial pneumonitis.
  • Profound bone marrow suppression leading to pancytopenia.
  • Acute renal failure.
  • Life‑threatening cutaneous reactions such as Stevens‑Johnson syndrome.
  • Opportunistic infections due to immunosuppression.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated (Category X); avoid use in pregnant or planning women.
  • Renal function: assess baseline and monitor; dose adjustment may be needed.
  • Hepatic health: perform liver function tests before and during therapy.
  • Hematologic status: regular blood counts to detect myelosuppression.
  • Concomitant drugs: review for interactions that may increase toxicity.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Methotrexate interacts with several drug classes that can alter its safety profile.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Penicillins and other β‑lactam antibiotics: reduce renal clearance, raising plasma levels.
  • Proton pump inhibitors: may elevate methotrexate concentrations.

Moderate Interactions (Monitor Closely)

  • Sulfonamide antibiotics: heightened risk of myelosuppression.
  • Live vaccines: increased chance of infection due to immunosuppression.

Frequently Asked Questions

Metotab contains methotrexate and is prescribed for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and ectopic pregnancy. It works by suppressing abnormal immune activity and inhibiting the growth of malignant cells in these specific diseases.

Methotrexate blocks dihydrofolate reductase, an enzyme needed for folate metabolism. This inhibition stops the formation of nucleotides required for DNA synthesis, leading to reduced proliferation of rapidly dividing cells such as immune cells and cancer cells.

The exact dose of Metotab is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and treatment goals. Dosage regimens vary widely across the different indications and must be individualized.

Methotrexate is classified as pregnancy category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. It is also not recommended while breastfeeding because it can be excreted in breast milk.

To request Metotab, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metotab (methotrexate) is a first‑line folate antagonist widely used for both autoimmune and oncologic conditions. Compared with newer agents, it is less expensive but requires careful monitoring for toxicity. Its efficacy is well‑established across multiple disease areas.

Metotab should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Metotab is taken orally as a tablet. The prescriber will advise whether it should be taken with food or on an empty stomach and will provide instructions on the timing and frequency of each dose.

Serious risks include severe liver toxicity, pulmonary fibrosis, profound bone‑marrow suppression leading to pancytopenia, and acute renal failure. Patients should be monitored regularly for signs of these complications and report any concerning symptoms promptly.

Metotab is contraindicated in pregnant women, individuals with severe liver or kidney impairment, and patients with known hypersensitivity to methotrexate or any component of the formulation. It should also be avoided in patients receiving certain interacting medications without close supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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