Metotab (Methotrexate Disodium)

Methotrexate blocks the enzyme dihydrofolate reductase, preventing the formation of tetrahydrofolate, a key cofactor for making purine nucleotides and thymidylate. Without these building blocks, DNA, RNA and protein synthesis are reduced, limiting the proliferation of rapidly dividing cells such as cancer cells and activated immune cells.

The dose of Metotab is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and treatment response. No universal dosing schedule is provided here; the prescriber will set the appropriate regimen for each patient.

Methotrexate is classified as pregnancy category X because it is teratogenic and can cause fetal malformations or loss. It is also not recommended while breastfeeding, as it may be excreted in milk and affect the infant. Effective contraception is required for both men and women of reproductive potential.

To request Metotab, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Compared with biologic agents that target specific cytokines, methotrexate offers a broad‑acting, oral option that is less costly but requires careful monitoring for toxicity. Within antimetabolites, methotrexate is distinguished by its folate‑antagonist mechanism, making it effective for both oncologic and autoimmune indications, whereas agents like 5‑fluorouracil are more cancer‑specific.

Metotab should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister or container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Metotab is taken orally with a full glass of water, usually on an empty stomach to improve absorption. The prescriber may advise specific timing relative to meals or other medications. Patients should follow the exact schedule provided and not alter the dose without medical guidance.

The most critical adverse effects include severe liver injury or fibrosis, bone‑marrow suppression leading to pancytopenia, and pulmonary toxicity such as interstitial pneumonitis. Early detection through regular laboratory monitoring and prompt reporting of symptoms like persistent cough, jaundice, or unusual bruising is essential.

Metotab is contraindicated in pregnant or breastfeeding individuals, patients with severe renal or hepatic impairment, and those with known hypersensitivity to methotrexate or its excipients. Caution is also advised for patients with active infections, uncontrolled diabetes, or a history of pulmonary disease.