Product image of Metotreksat Ebewe (Methotrexate) supplied by GNH India

Metotreksat Ebewe

Active Ingredient:
Methotrexate
Origin:
EU

Metotreksat Ebewe (Methotrexate)

Methotrexate, the active ingredient in Metotreksat Ebewe, is an antimetabolite (folate antagonist) presented as an intravenous solution for parenteral use. It is employed in the management of autoimmune disorders and certain malignancies, acting on rapidly dividing cells.
GNH India supplies Metotreksat Ebewe as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ebewe Pharma

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Indications & Clinical Uses

  • Methotrexate is used across several disease families, primarily targeting immune‑mediated and proliferative conditions.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin lesion severity and plaque formation.
  • Acute lymphoblastic leukemia: interferes with leukemic cell replication.
  • Osteosarcoma: used as part of multi‑agent chemotherapy protocols.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the synthesis of purine nucleotides and thymidylate, leading to impaired DNA synthesis and cell replication, particularly affecting rapidly dividing immune and cancer cells.

Side Effects

Methotrexate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Fatigue or malaise
  • Oral mucosal ulceration
  • Transient elevation of liver enzymes
  • Mild alopecia
  • Decreased white blood cell count

Serious or Rare Side Effects

  • Severe hepatotoxicity or fibrosis
  • Pulmonary toxicity (interstitial pneumonitis)
  • Bone marrow failure leading to pancytopenia
  • Acute renal failure
  • Life‑threatening infection due to immunosuppression
  • Anaphylactic or severe hypersensitivity reactions

Precautions & Warnings

  • Before initiating therapy, clinicians should assess baseline health status and monitor patients regularly.
  • Monitor blood counts: perform complete blood count before each dose.
  • Assess liver function: check transaminases and bilirubin regularly.
  • Evaluate renal function: measure serum creatinine and adjust dosing as needed.
  • Avoid in pregnancy: contraindicated due to teratogenic risk.
  • Review concomitant nephrotoxic or hepatotoxic drugs: adjust or discontinue as appropriate.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medications that can alter its safety or efficacy.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Trimethoprim‑sulfamethoxazole: potentiates bone marrow suppression.
  • Live vaccines: risk of severe infection.
  • Azathioprine or other immunosuppressants: additive myelosuppression.
  • High‑dose penicillins: may reduce renal clearance.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may increase serum methotrexate levels.
  • Sulfonamide antibiotics: potential additive hematologic effects.
  • Antacids containing aluminum or magnesium: may affect absorption of oral forms.
  • Phenytoin: may alter hepatic metabolism.
  • Vitamin supplements containing folic acid: may reduce efficacy, requiring dose adjustment.

Frequently Asked Questions

Metotreksat Ebewe contains methotrexate, which is prescribed for autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as for certain cancers including acute lymphoblastic leukemia and osteosarcoma. The specific indication is determined by the treating physician based on the patient’s diagnosis.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing the production of tetrahydrofolate needed for DNA synthesis. This inhibition limits the replication of rapidly dividing cells, which includes immune cells involved in inflammation and malignant cells in various cancers.

The dosing regimen for Metotreksat Ebewe is individualized. A qualified prescriber determines the dose, frequency, and duration based on the patient’s condition, weight, renal and hepatic function, and response to therapy.

Methotrexate is classified as teratogenic and is contraindicated in pregnancy. Women of child‑bearing potential must use effective contraception. Breastfeeding is not recommended while receiving methotrexate because the drug can be excreted in milk and may harm the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Metotreksat Ebewe is a methotrexate formulation intended for intravenous administration, offering rapid systemic exposure compared with oral tablets. Intravenous delivery can be advantageous for patients requiring higher doses, those with gastrointestinal absorption issues, or when a controlled infusion schedule is needed.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and potency.

Metotreksat Ebewe is given by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and duration are set by the prescriber, and patients are monitored for any immediate adverse reactions during and after the administration.

Serious risks include severe liver toxicity, pulmonary fibrosis, bone marrow failure leading to pancytopenia, acute renal failure, and life‑threatening infections due to immunosuppression. Patients should be monitored closely for signs of organ dysfunction and infection.

Metotreksat Ebewe is contraindicated in pregnant women, individuals with known hypersensitivity to methotrexate, patients with severe hepatic or renal impairment, and those with active, uncontrolled infections. It should also be avoided in patients receiving live vaccines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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