Product image of Metotrexat Accord (Methotrexate) supplied by GNH India

Metotrexat Accord

Active Ingredient:
Methotrexate
Origin:
EU

Metotrexat Accord (Methotrexate)

Methotrexate, the active ingredient in Metotrexat Accord, is an antimetabolite (folate antagonist) presented as a sterile injectable solution for intra‑arterial, intramuscular, and intrathecal administration. It is used to treat autoimmune disorders and certain malignancies in adult patients.

GNH India supplies Metotrexat Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide. The company ensures quality assurance, regulatory compliance, and reliable cold‑chain logistics where required, facilitating consistent product availability across global markets with dedicated technical support for end‑users.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methotrexate is employed across several disease categories, primarily targeting rapidly dividing cells and immune‑mediated pathways.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin lesion formation and severity.
  • Acute lymphoblastic leukemia: induces remission by inhibiting leukemic cell proliferation.
  • Non‑Hodgkin lymphoma: contributes to tumor control through cytotoxic activity.
  • Breast cancer: used as adjuvant therapy to limit tumor growth.
  • Ectopic pregnancy: terminates trophoblastic tissue by disrupting DNA synthesis.

How It Works

  • Methotrexate competitively inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This depletion of tetrahydrofolate limits the synthesis of purine and pyrimidine nucleotides, impairing DNA, RNA and protein production. The resulting inhibition of cell replication particularly affects rapidly dividing immune cells and malignant cells, providing immunosuppressive and antineoplastic effects. Additionally, methotrexate can increase extracellular adenosine levels, contributing to its anti‑inflammatory properties.

Side Effects

Methotrexate may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Fatigue or malaise
  • Oral mucositis (mouth sores)
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Severe hepatic toxicity or fibrosis
  • Pulmonary fibrosis or interstitial pneumonitis
  • Bone marrow suppression leading to pancytopenia
  • Acute renal failure or nephrotoxicity

Precautions & Warnings

When using methotrexate, careful monitoring and patient counseling are essential to minimize risks.

  • Monitor blood counts: perform regular complete blood count tests to detect cytopenias.
  • Assess liver function: conduct periodic liver enzyme tests to identify hepatotoxicity.
  • Evaluate renal function: check serum creatinine and clearance before and during therapy.
  • Avoid use in pregnancy: methotrexate is contraindicated due to teratogenic risk; ensure effective contraception.
  • Counsel on infection risk: advise patients to report signs of infection promptly.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Methotrexate interacts with several medicines; some combinations must be avoided while others require close monitoring.

Major Interactions (Avoid)

  • NSAIDs: increase methotrexate toxicity by reducing renal clearance.
  • Trimethoprim‑sulfamethoxazole: additive bone‑marrow suppression.
  • Live vaccines: heightened risk of infection due to immunosuppression.
  • Azathioprine or other immunosuppressants: may cause excessive immunosuppression.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may affect gastrointestinal absorption.
  • Phenytoin and other enzyme inducers: can lower methotrexate plasma levels.
  • Alcohol: potentiates hepatic toxicity.
  • Folate supplements: may reduce efficacy; adjust dosing under medical guidance.

Frequently Asked Questions

Metotrexat Accord contains methotrexate, which is indicated for rheumatoid arthritis, severe plaque psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, certain breast cancer protocols, and medically managed ectopic pregnancy. The drug works by targeting rapidly dividing cells and modulating immune activity in these disorders.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing tetrahydrofolate levels needed for DNA, RNA and protein synthesis. This inhibition hampers the growth of rapidly proliferating cells, such as immune cells and cancer cells, and also raises extracellular adenosine, which contributes to anti‑inflammatory effects.

The dose of Metotrexat Accord is individualized by the prescribing healthcare professional based on the specific indication, disease severity, patient weight, renal and hepatic function, and concurrent therapies. No fixed regimen can be provided here; dosing decisions are made by qualified clinicians.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal malformations and loss. It is also excreted in breast milk and may harm a nursing infant, so breastfeeding is not recommended while receiving the drug.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Metotrexat Accord. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Methotrexate is a small‑molecule antimetabolite that directly interferes with folate metabolism, whereas many biologic agents target specific cytokines or cell‑surface receptors. Compared with biologics, methotrexate is generally less expensive and administered via injection, but it may have a broader side‑effect profile and requires regular laboratory monitoring.

Metotrexat Accord should be stored at ambient temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain stability and potency.

The medication is supplied as a sterile injectable solution and can be given by intra‑arterial, intramuscular, or intrathecal injection, depending on the clinical indication and prescribing physician’s instructions. Administration is performed by qualified healthcare personnel in an appropriate clinical setting.

Serious adverse events include severe hepatic toxicity or fibrosis, pulmonary fibrosis or interstitial pneumonitis, profound bone‑marrow suppression leading to pancytopenia, and acute renal failure. Patients should be monitored closely for signs of organ dysfunction, and therapy should be discontinued if any of these severe reactions occur.

Methotrexate is contraindicated in pregnant women, individuals with known hypersensitivity to the drug, patients with severe hepatic or renal impairment, and those with active, uncontrolled infections. Caution is also advised for patients with pre‑existing blood dyscrasias or pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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