Product image of Metotrexat Vitema (Methotrexate) supplied by GNH India

Metotrexat Vitema

Active Ingredient:
Methotrexate
Origin:
EU

Metotrexat Vitema (Methotrexate)

Methotrexate, the active ingredient in Metotrexat Vitema, is an antimetabolite (folate antagonist) presented as an oral formulation for systemic use. It is employed to manage autoimmune disorders and certain cancers in adult patients. GNH India supplies Metotrexat Vitema as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vitema S.A.

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Indications & Clinical Uses

Methotrexate acts on rapidly dividing cells and immune pathways, making it useful in several disease families.

  • Rheumatoid arthritis: reduces joint inflammation and slows structural damage.
  • Psoriasis: limits skin cell proliferation and improves plaque lesions.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication as part of chemotherapy protocols.
  • Other neoplastic diseases: provides antineoplastic activity in selected solid tumours and lymphomas.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the regeneration of tetrahydrofolate. This blocks the synthesis of purine and pyrimidine nucleotides, thereby disrupting DNA, RNA and protein production. The resulting antiproliferative effect targets rapidly dividing malignant cells and modulates immune cell activity, contributing to its antineoplastic and immunosuppressive actions.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue or general weakness.
  • Oral mucosal ulceration (stomatitis).
  • Elevated liver enzymes.
  • Decreased blood cell counts (leukopenia, anemia, thrombocytopenia).
  • Hair thinning or loss.

Serious or Rare Side Effects

  • Severe bone‑marrow suppression leading to pancytopenia.
  • Acute or chronic liver toxicity, including fibrosis.
  • Pulmonary toxicity such as interstitial pneumonitis.
  • Life‑threatening infections due to immunosuppression.
  • Renal impairment or failure.
  • Severe hypersensitivity reactions, including Stevens‑Johnson syndrome.

Precautions & Warnings

Careful monitoring and patient education are essential when using methotrexate.

  • Monitor blood counts: perform regular complete blood count tests.
  • Assess liver function: check hepatic enzymes before and during therapy.
  • Evaluate renal function: adjust dose if creatinine clearance is reduced.
  • Avoid use in pregnancy unless absolutely necessary: discuss contraception with women of child‑bearing potential.
  • Review folate supplementation: consider prescribing folic acid to reduce mucosal toxicity.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Methotrexate may interact with several concomitant medicines, requiring dose adjustments or avoidance.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Trimethoprim: potentiates hematologic suppression.
  • Live vaccines: risk of severe infection.

Moderate Interactions (Monitor Closely)

  • Penicillins: may enhance renal clearance.
  • Sulfonamides: can increase plasma methotrexate levels.
  • Azathioprine: additive immunosuppressive effect.

Frequently Asked Questions

Metotrexat Vitema, containing methotrexate, is prescribed for rheumatoid arthritis, moderate to severe plaque psoriasis, acute lymphoblastic leukaemia and other selected neoplastic diseases where inhibition of cell proliferation is required.

Methotrexate blocks the enzyme dihydrofolate reductase, which stops the formation of tetrahydrofolate. Without this co‑factor, DNA, RNA and protein synthesis are disrupted, leading to reduced proliferation of immune cells and malignant cells.

The dose of methotrexate is individualized by the prescribing clinician based on the specific indication, patient weight, renal function and treatment response. Only a qualified health professional should determine the appropriate regimen.

Methotrexate is generally contraindicated in pregnancy because of its known teratogenic potential. Women of child‑bearing potential should use effective contraception. Limited data exist for breastfeeding, and the drug is usually avoided unless the benefit outweighs the risk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with biologic agents, methotrexate is an oral, lower‑cost option with a well‑established efficacy profile for rheumatoid arthritis and psoriasis. Unlike azathioprine, it directly inhibits folate metabolism, offering a different safety and monitoring profile that may be preferred in certain patient groups.

Store Metotrexat Vitema tablets at ambient temperature, below 25 °C, in the original blister or bottle. Keep the container tightly closed, protect from moisture and direct sunlight, and discard any tablets that appear discoloured or damaged.

Metotrexat Vitema is taken orally, usually with a full glass of water. Depending on the prescribing information, it may be taken with or without food; some clinicians advise taking it on an empty stomach to improve absorption, while others recommend food to reduce gastrointestinal upset.

The most critical adverse events include severe bone‑marrow suppression leading to pancytopenia, significant liver toxicity that can progress to fibrosis or cirrhosis, and pulmonary complications such as interstitial pneumonitis. Prompt monitoring of blood counts, liver enzymes and respiratory symptoms is essential.

Patients with known hypersensitivity to methotrexate, active severe liver disease, uncontrolled infections, significant renal impairment, or those who are pregnant should avoid Metotrexat Vitema. Clinicians must also assess for contraindications such as recent live‑vaccine administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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