Product image of Metotrexato Aurobindo (Methotrexate) supplied by GNH India

Metotrexato Aurobindo

Active Ingredient:
Methotrexate
Origin:
EU

Metotrexato Aurobindo (Methotrexate)

Methotrexate, the active ingredient in Metotrexato Aurobindo, is an antimetabolite and immunosuppressant presented as an oral tablet for oral use. It is used to manage autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as to treat several malignancies including acute lymphoblastic leukemia and non‑Hodgkin lymphoma in adult patients.

GNH India supplies Metotrexato Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards, is available for global distribution, and ensures quality and reliability.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Methotrexate acts on rapidly dividing cells and modulates immune pathways, making it useful in several inflammatory and oncologic conditions.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: diminishes skin lesions and plaque formation.
  • Acute lymphoblastic leukemia: interferes with leukemic cell proliferation.
  • Non‑Hodgkin lymphoma: impedes malignant lymphoid growth.
  • Gestational trophoblastic disease: promotes resolution of trophoblastic tissue.
  • Osteosarcoma: limits tumor cell replication.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate. This reduction limits the synthesis of purine nucleotides and thymidylate, leading to decreased DNA, RNA, and protein production, which suppresses rapidly dividing immune and cancer cells.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea and vomiting.
  • Stomatitis or mouth ulcers.
  • Fatigue or malaise.
  • Alopecia (hair loss).
  • Elevated liver enzymes.
  • Mild skin rash.

Serious or Rare Side Effects

  • Bone marrow suppression leading to pancytopenia.
  • Severe hepatotoxicity or fibrosis.
  • Pulmonary toxicity, including interstitial pneumonitis.
  • Renal failure due to crystal nephropathy.
  • Life‑threatening infections.

Precautions & Warnings

Before initiating therapy, several precautions should be observed to minimize risk.

  • Liver monitoring: check hepatic enzymes regularly.
  • Blood counts: perform complete blood count before and during treatment.
  • Renal function: assess creatinine clearance and adjust dose if impaired.
  • Pregnancy: contraindicated in pregnancy; ensure effective contraception.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Methotrexate interacts with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Penicillins (e.g., ampicillin): can raise serum methotrexate levels.
  • Sulfonamide antibiotics: may potentiate adverse effects.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may affect renal clearance.
  • Azathioprine or leflunomide: additive immunosuppression.
  • Live vaccines: risk of infection due to immunosuppression.

Frequently Asked Questions

Metotrexato Aurobindo contains methotrexate, which is prescribed for autoimmune conditions such as rheumatoid arthritis and psoriasis, as well as for certain cancers including acute lymphoblastic leukemia, non‑Hodgkin lymphoma, gestational trophoblastic disease, and osteosarcoma.

Methotrexate blocks dihydrofolate reductase, an enzyme needed for folate metabolism. This inhibition reduces the synthesis of DNA, RNA and proteins, thereby limiting the growth of rapidly dividing immune cells and cancer cells.

The dose of methotrexate is individualized by the prescribing healthcare professional based on the specific indication, patient characteristics, and response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Methotrexate is classified as pregnancy category X and is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Methotrexate is often considered a first‑line disease‑modifying antirheumatic drug (DMARD) because of its proven efficacy and oral administration. Compared with biologic agents, it is less expensive but may require monitoring for toxicity. Choice of therapy depends on disease severity, patient tolerance and comorbidities.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat and direct sunlight to maintain stability and potency.

Metotrexato Aurobindo is taken orally as a tablet with a full glass of water. The prescriber will specify whether it should be taken with food or on an empty stomach, and the exact dosing schedule.

The most serious risks include bone‑marrow suppression leading to pancytopenia, severe liver toxicity or fibrosis, and pulmonary toxicity such as interstitial pneumonitis. Patients should be monitored regularly for these complications.

Methotrexate should not be used by pregnant women, individuals with severe liver disease, uncontrolled renal impairment, active infections, or those who are hypersensitive to methotrexate or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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