Product image of Metrocreme (Metronidazole) supplied by GNH India

Metrocreme

Active Ingredient:
Metronidazole
Origin:
EU

Metrocreme (Metronidazole)

Metronidazole, the active ingredient in Metrocreme, is a Nitroimidazole presented as a topical formulation for skin use. It is indicated for conditions such as rosacea, acne vulgaris, and other skin infections, and is applied directly to the affected area under medical supervision, providing antimicrobial and anti‑inflammatory effects for adult patients.

GNH India supplies Metrocreme as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing standards, regulatory adherence, and reliable global logistics for healthcare providers.

Manufacturer / TM Owner

Galderma Laboratorium Gmbh

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Indications & Clinical Uses

Metronidazole is used topically to treat bacterial and inflammatory skin disorders.

  • Rosacea: reduces erythema and papulopustular lesions.
  • Acne vulgaris: decreases inflammatory lesions and bacterial load.
  • Dermatological infections: eradicates susceptible anaerobic bacteria and promotes healing.

How It Works

  • Metronidazole penetrates microbial cells and undergoes reduction of its nitro group, generating reactive intermediates that damage DNA and inhibit nucleic acid synthesis in anaerobic organisms. In skin, it also modulates inflammatory pathways, reducing cytokine release and leukocyte infiltration, which contributes to its anti‑inflammatory activity.

Side Effects

Topical metronidazole may cause local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild burning or stinging at the application site.
  • Itching: localized pruritus.
  • Dryness: transient skin dryness.
  • Redness: mild erythema.
  • Contact dermatitis: allergic skin reaction.
  • Peeling: superficial desquamation.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis or angioedema.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Extensive skin ulceration or necrosis.
  • Systemic neurotoxicity: peripheral neuropathy (rare with significant absorption).

Precautions & Warnings

When using Metrocreme, consider the following safety measures.

  • Pregnancy: safety not established; consult a healthcare professional before use.
  • Breastfeeding: unknown risk; weigh benefits against potential infant exposure.
  • Extensive broken skin: avoid application on large open wounds.
  • Concomitant topical antibiotics: do not combine without medical advice.
  • Allergic reactions: monitor for signs of hypersensitivity.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metronidazole may interact with other medicines when absorbed systemically.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: heightened risk of lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce metronidazole efficacy.
  • Other nitroimidazoles: additive toxicity potential.
  • Oral metronidazole: increased systemic exposure, monitor for side effects.

Frequently Asked Questions

Metrocreme is a topical formulation containing metronidazole that is used to manage rosacea, acne vulgaris, and other dermatological infections caused by susceptible anaerobic bacteria. It is applied directly to the affected skin under the guidance of a healthcare professional.

Metronidazole penetrates bacterial cells and is reduced to reactive intermediates that damage DNA, inhibiting nucleic acid synthesis in anaerobic microorganisms. In the skin, it also dampens inflammatory pathways, reducing cytokine release and leukocyte activity, which helps control inflammation.

The dosage of Metrocreme is determined by the prescribing clinician based on the specific indication, severity of the condition, and patient factors. The prescriber will provide instructions on the amount to apply and frequency of use.

Safety data for topical metronidazole in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Metrocreme to pregnant or breastfeeding individuals.

To order Metrocreme, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metrocreme’s metronidazole offers both antimicrobial and anti‑inflammatory actions, which distinguishes it from many topical antibiotics that primarily target bacteria. Compared with agents such as clindamycin, metronidazole may be preferred for patients with inflammatory lesions and a risk of anaerobic infection.

Metrocreme should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and efficacy.

Metrocreme is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually once or twice daily, as directed by the prescriber. Hands should be washed before and after application.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and rare systemic neurotoxicity if significant absorption occurs. Patients should seek immediate medical attention if they notice signs of severe skin reactions or systemic symptoms.

Metrocreme should be avoided in individuals with known hypersensitivity to metronidazole or any component of the formulation, and in patients with extensive open wounds or severe skin barrier disruption unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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