Product image of Metrogalen (Metronidazole) supplied by GNH India

Metrogalen

Active Ingredient:
Metronidazole
Origin:
EU

Metrogalen (Metronidazole)

Metronidazole, the active ingredient in Metrogalen, is a nitroimidazole antibiotic presented as a topical formulation for cutaneous use. It treats bacterial skin infections and certain protozoal conditions, such as rosacea and acne vulgaris, in adult patients.

GNH India supplies Metrogalen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets European Union quality standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Galenpharma Gmbh

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic used topically to manage bacterial and protozoal skin disorders.

  • Rosacea: reduces inflammatory lesions and erythema associated with the condition.
  • Acne vulgaris: decreases acne lesions by targeting anaerobic bacteria and reducing inflammation.
  • Bacterial skin infections: treats localized infections such as impetigo and folliculitis by eradicating susceptible organisms.

How It Works

  • Metronidazole is reduced by anaerobic microorganisms to reactive nitro radicals that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis. This selective toxicity disrupts microbial replication while sparing aerobic host cells, leading to eradication of susceptible bacteria and protozoa in the treated skin area.

Side Effects

Topical metronidazole may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation: mild redness, burning, or stinging at the application site.
  • Dryness: localized dryness or flaking of the treated skin.
  • Pruritus: itching sensation that may accompany irritation.
  • Contact dermatitis: allergic skin reaction presenting as rash or swelling.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, angioedema, or widespread urticaria.
  • Stevens‑Johnson syndrome: rare severe mucocutaneous reaction.
  • Systemic toxicity: rare systemic absorption leading to neurotoxicity or hepatic effects.

Precautions & Warnings

When using Metrogalen, consider the following safety measures.

  • Limit application area: apply only to the prescribed skin region to minimize systemic absorption.
  • Avoid broken skin: do not apply on open wounds or extensive dermatitis.
  • Monitor for allergy: discontinue use if signs of hypersensitivity develop.
  • Pregnancy and lactation: use only if clearly indicated and prescribed by a healthcare professional.
  • Interactions with alcohol: advise patients to avoid alcohol consumption to reduce risk of disulfiram‑like reactions.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with other substances; awareness of the interaction level helps guide safe use.

Major Interactions (Avoid)

  • Alcohol: concurrent intake may cause a disulfiram‑like reaction with flushing, nausea, and tachycardia.
  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Lithium: concurrent use may increase lithium levels; monitor serum concentrations.
  • Cytochrome P450 inducers (e.g., rifampicin, carbamazepine): may reduce metronidazole efficacy.
  • Other topical antibiotics: concurrent use may increase local irritation; assess skin tolerance.

Frequently Asked Questions

Metrogalen is a topical formulation of metronidazole indicated for the treatment of rosacea, acne vulgaris, and localized bacterial skin infections such as impetigo and folliculitis. It works by targeting anaerobic microorganisms that contribute to inflammation and lesion formation on the skin.

Metronidazole is reduced within anaerobic microorganisms to generate reactive nitro radicals. These radicals bind to microbial DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death of the targeted bacteria and protozoa while sparing human cells.

The specific dosage and frequency of Metrogalen are determined by the prescribing healthcare professional based on the patient’s condition, severity, and treatment area. Patients should follow the prescriber’s instructions and the product label carefully.

Safety of topical metronidazole during pregnancy or lactation has not been definitively established. It should be used only if clearly needed and prescribed by a qualified clinician, weighing potential benefits against any possible risks to the mother and infant.

To order Metrogalen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Metrogalen (metronidazole) differs from many topical acne agents such as clindamycin or benzoyl peroxide by targeting anaerobic bacteria and protozoal organisms, offering anti‑inflammatory benefits especially useful in rosacea. Its safety profile and mechanism make it a valuable alternative when conventional antibiotics are unsuitable or resistance is a concern.

Metrogalen should be stored below 25 °C in its original packaging, protected from moisture and direct light. Keeping the product in a cool, dry place helps maintain its stability and efficacy throughout its shelf life.

Metrogalen is applied topically to the affected skin area, typically once or twice daily as directed by the prescriber. The skin should be clean and dry before application, and the medication should be spread in a thin layer without rubbing vigorously.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and systemic toxicity from excessive absorption. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, swelling, difficulty breathing, or unexplained neurological symptoms.

Metrogalen should not be used by individuals with known hypersensitivity to metronidazole or any component of the formulation. It is also contraindicated on extensive broken skin, in patients with severe liver disease without medical supervision, and in those who are unable to avoid alcohol consumption while using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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