Product image of Metrogel (Metronidazole) supplied by GNH India

Metrogel

Active Ingredient:
Metronidazole
Origin:
EU

Metrogel (Metronidazole)

Metronidazole, the active ingredient in Metrogel, is a nitroimidazole antibiotic presented as a gel for topical (cutaneous) use. It treats inflammatory skin conditions such as rosacea in adults.
GNH India supplies Metrogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Galderma Laboratorium Gmbh

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Indications & Clinical Uses

Metrogel contains metronidazole, a nitroimidazole that acts on skin inflammation and microbial colonisation associated with rosacea.

  • Rosacea: reduces inflammatory papules, pustules and persistent facial erythema.

How It Works

  • Metronidazole penetrates the stratum corneum and is reduced in anaerobic microorganisms and inflammatory cells. The reduced form generates toxic nitro radicals that damage DNA and other macromolecules, inhibiting nucleic acid synthesis and leading to bacterial and protozoal cell death while also modulating host inflammatory pathways.

Side Effects

Topical metronidazole gel may cause local skin reactions.

Common Side Effects

  • Burning sensation at the application site
  • Stinging or tingling feeling
  • Dryness or flaking of the skin
  • Itching or mild pruritus
  • Redness or mild erythema
  • Peeling or scaling

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis)
  • Contact dermatitis with extensive rash
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Persistent ulceration or necrosis of the skin
  • Systemic absorption leading to gastrointestinal upset (very rare)

Precautions & Warnings

Before using Metrogel, consider the following safety points.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Broken or ulcerated skin: avoid application on compromised skin.
  • Concurrent topical antibiotics: use only under medical guidance.
  • Severe irritation: discontinue and seek medical advice.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole gel can interact with other topical agents and systemic medications.

Major Interactions (Avoid)

  • Systemic metronidazole therapy: avoid simultaneous use to prevent cumulative exposure.
  • Known hypersensitivity to nitroimidazoles: contraindicated.

Moderate Interactions (Monitor Closely)

  • Topical retinoids or exfoliants: may increase local irritation.
  • Other topical antibiotics (e.g., clindamycin): monitor for additive skin reactions.
  • Alcohol‑based skin products: may enhance burning sensation.
  • UV exposure: increased photosensitivity risk, advise sun protection.

Frequently Asked Questions

Metrogel is a topical gel that contains metronidazole and is primarily indicated for the treatment of rosacea. It helps reduce inflammatory lesions, papules, pustules, and persistent facial redness associated with the condition.

Metronidazole penetrates skin cells and is reduced in anaerobic microorganisms and inflammatory cells, forming nitro radicals that damage DNA and inhibit nucleic acid synthesis. This antimicrobial action, together with anti‑inflammatory effects, reduces the skin changes seen in rosacea.

The dosage of Metrogel is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected facial areas once or twice daily, but the exact regimen should follow the prescriber’s instructions.

Safety data for topical metronidazole during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Metrogel.

To request Metrogel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metrogel (metronidazole) is a nitroimidazole with both antimicrobial and anti‑inflammatory properties, making it a first‑line topical option. Alternatives such as azelaic acid, ivermectin cream, or doxycycline oral tablets have different mechanisms; choice depends on severity, patient tolerance and physician preference.

Metrogel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, heat and direct sunlight to maintain product stability.

Apply a thin layer of Metrogel to clean, dry skin on the affected facial areas, usually once or twice daily as directed by a healthcare professional. Gently massage until the gel is evenly spread, avoiding the eyes and mucous membranes.

Serious risks, though rare, include severe allergic reactions such as angio‑edema, anaphylaxis, and severe skin disorders like Stevens‑Johnson syndrome or toxic epidermal necrolysis. Immediate medical attention is required if any of these symptoms develop.

Individuals with a known hypersensitivity to metronidazole, other nitroimidazoles, or any component of the gel should avoid using Metrogel. It is also contraindicated on broken, ulcerated or severely inflamed skin without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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