Product image of Metrogel (Metronidazole) supplied by GNH India

Metrogel

Active Ingredient:
Metronidazole
Origin:
EU

Metrogel (Metronidazole)

Metronidazole, the active ingredient in Metrogel, is a nitroimidazole presented as a gel for topical use. It treats rosacea and related facial skin inflammation in adults.\n\nGNH India supplies Metrogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Galderma (U.K.) Limited

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Indications & Clinical Uses

  • Metronidazole is an antiprotozoal nitroimidazole used primarily in dermatology for inflammatory skin disorders.\n\nPapulopustular rosacea: reduces papules and pustules.\nErythematotelangiectatic rosacea: diminishes facial redness and visible blood vessels.\nGeneralized facial erythema: improves overall skin tone and reduces persistent redness.

How It Works

  • Metronidazole is reduced within anaerobic microorganisms, generating reactive nitro radicals that cause DNA strand breakage and inhibit nucleic acid synthesis. In skin cells, these actions suppress inflammatory mediators and bacterial overgrowth, leading to reduced erythema and lesion formation associated with rosacea.

Side Effects

  • Topical metronidazole may cause local skin reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Burning sensation at the application site\n- Stinging or tingling feeling\n- Dryness or flaking of the skin\n- Itching or mild pruritus\n- Redness or mild erythema\n- Slight swelling or edema\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (e.g., angioedema)\n- Contact dermatitis with blistering\n- Extensive skin ulceration\n- Anaphylaxis (rare)\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Persistent discoloration of the skin

Precautions & Warnings

  • Use Metrogel only as directed and consider patient‑specific factors before application.\n\nPregnancy: safety not established; avoid unless benefit outweighs risk.\nBreastfeeding: unknown safety; consult a healthcare professional.\nBroken skin: do not apply to open wounds or irritated areas.\nConcurrent alcohol use: may increase local irritation.\nEye contact: avoid applying near the eyes; rinse thoroughly if contact occurs.\nStore at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

  • Topical metronidazole may interact with other agents applied to the same skin area.\n\nMajor Interactions (Avoid):\n- Systemic metronidazole: concurrent use may increase systemic exposure.\n- Other topical nitroimidazoles: avoid combined use to prevent additive irritation.\n\nModerate Interactions (Monitor Closely):\n- Topical corticosteroids: may mask local irritation signs.\n- Alcohol‑based moisturizers: can enhance skin burning.\n- Photosensitizing agents: increase risk of sunburn when exposed to UV light.

Frequently Asked Questions

Metrogel is a topical gel containing metronidazole that is primarily prescribed to manage the signs of rosacea, including facial redness, papules, and pustules. It helps reduce inflammation and improve skin appearance in affected adults.

Metronidazole is reduced inside anaerobic microorganisms and skin cells, producing reactive nitro radicals that break DNA strands and inhibit nucleic acid synthesis. This action reduces bacterial overgrowth and suppresses inflammatory mediators, leading to decreased redness and lesions.

The dosage of Metrogel is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected facial areas once or twice daily, but the exact regimen should follow the prescriber’s instructions.

Safety of Metrogel in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk, and the decision should be made in consultation with a qualified healthcare provider.

To order Metrogel, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metrogel’s active ingredient, metronidazole, is a nitroimidazole with anti‑inflammatory and antimicrobial properties. Compared with azelaic acid or ivermectin creams, metronidazole is often well‑tolerated and effective for papulopustular rosacea, though individual response may vary.

Metrogel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing the gel.

Clean and gently pat the affected facial skin dry. Apply a thin, even layer of Metrogel to the rosacea‑affected areas, usually once or twice daily, as directed by the prescriber. Avoid contact with eyes, lips and broken skin.

Serious risks, though rare, include severe allergic reactions such as angioedema, contact dermatitis with blistering, extensive skin ulceration, and life‑threatening conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice worsening skin reactions.

Metrogel should not be used by individuals with known hypersensitivity to metronidazole or any component of the formulation, on broken or severely irritated skin, or in conjunction with systemic metronidazole without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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