Product image of Metronidazol Actavis (Metronidazole) supplied by GNH India

Metronidazol Actavis

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Actavis (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Actavis, is a nitroimidazole antibiotic presented as a topical formulation for cutaneous use. It is employed to treat bacterial skin infections, rosacea and acne vulgaris in patients requiring topical antimicrobial therapy.

GNH India supplies Metronidazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Metronidazole is indicated for dermatologic conditions caused by anaerobic bacteria or protozoa, acting on the skin surface to reduce microbial load.

  • Bacterial skin infections: eliminates susceptible anaerobic bacteria, helping resolve cellulitis, impetigo and infected wounds.
  • Rosacea: reduces inflammatory lesions and erythema associated with papulopustular rosacea.
  • Acne vulgaris: decreases Propionibacterium acnes colonisation, improving acne lesions.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals interact with DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to bacterial cell death. The same process disrupts protozoal DNA, providing antiprotozoal activity on the skin.

Side Effects

Metronidazole may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation: burning, stinging or itching at the application site.
  • Dryness or peeling of the treated skin.
  • Redness or mild erythema.
  • Pruritus (itching).
  • Mild allergic dermatitis.
  • Transient discoloration of the skin.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe allergic reaction with swelling, hives or difficulty breathing.
  • Photosensitivity leading to exaggerated sunburn.
  • Persistent ulceration or necrosis of the skin.
  • Systemic toxicity if absorbed in large amounts.
  • Neurological symptoms such as seizures (very rare).

Precautions & Warnings

Before using Metronidazol Actavis, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to metronidazole or nitroimidazoles.
  • Skin integrity: avoid application on extensive open wounds or damaged skin.
  • Alcohol avoidance: do not consume alcohol during treatment to prevent disulfiram‑like reactions.
  • Monitor for severe reactions: discontinue and seek medical help if signs of Stevens‑Johnson syndrome appear.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, vomiting, and tachycardia.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: heightened lithium toxicity, leading to tremor, confusion, or renal issues.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma levels.
  • Isoniazid: potential for enhanced neurotoxicity.
  • Phenytoin: may reduce metronidazole efficacy, requiring dose adjustment.

Frequently Asked Questions

Metronidazol Actavis is a topical formulation of metronidazole used to treat bacterial skin infections, manage rosacea, and improve acne vulgaris. It works on the skin surface to reduce the growth of anaerobic bacteria and protozoa that contribute to these dermatologic conditions.

Metronidazole penetrates microbial cells and is reduced to reactive nitro radicals under anaerobic conditions. These radicals damage DNA and inhibit nucleic acid synthesis, leading to bacterial and protozoal cell death, thereby reducing infection and inflammation on the skin.

The specific dosage and frequency of Metronidazol Actavis are determined by the prescribing healthcare professional based on the severity of the condition, the area of skin involved, and patient factors. Patients should follow the prescriber’s instructions and the product label.

Safety data for topical metronidazole during pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any risks. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their clinician before starting treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details and any required import documentation.

Metronidazol Actavis belongs to the nitroimidazole class, offering both antibacterial and antiprotozoal activity, which differentiates it from many topical antibiotics that target only bacteria. It is particularly effective against anaerobic organisms and is often preferred for rosacea and acne where these microbes play a role.

Store Metronidazol Actavis at room temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight and extreme temperatures to maintain stability and potency throughout its shelf life.

The product is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually once or twice daily, as directed by the prescriber. Hands should be washed after application, and the treated area should not be covered with occlusive dressings unless advised.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare systemic toxicity if significant absorption occurs. Patients should discontinue use and seek immediate medical attention if they develop widespread rash, blistering, fever, or signs of an allergic reaction.

Individuals with a known hypersensitivity to metronidazole, other nitroimidazoles, or any component of the formulation should avoid this product. It is also contraindicated on large areas of broken or ulcerated skin, and in patients who cannot abstain from alcohol during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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