Product image of Metronidazol Actavis (Metronidazole) supplied by GNH India

Metronidazol Actavis

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Actavis (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Actavis, is a nitroimidazole antibiotic presented as an oral dosage form for oral use. It treats infections caused by anaerobic bacteria and certain protozoa in adults and children as prescribed.

GNH India supplies Metronidazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and protozoa.

  • Bacterial vaginosis: eliminates anaerobic bacteria to restore normal vaginal flora.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites in intestinal disease.
  • Giardiasis: clears Giardia lamblia infection from the gastrointestinal tract.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in tissue infections.
  • Clostridioides difficile infection: reduces toxin‑producing C. difficile in the colon.

How It Works

  • Metronidazole enters susceptible anaerobic microorganisms and is reduced by intracellular electron‑transport proteins to generate nitro radical anions. These reactive intermediates bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, ultimately leading to cell death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing head pain.
  • Diarrhea: loose stools during treatment.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Liver toxicity: elevated enzymes or jaundice.
  • Blood dyscrasias: abnormal blood counts such as neutropenia.

Precautions & Warnings

Before using Metronidazol Actavis, consider the following safety measures.

  • Pregnancy: consult a healthcare provider as safety data are limited.
  • Breastfeeding: evaluate risk versus benefit; metronidazole may pass into milk.
  • Alcohol consumption: avoid alcohol to prevent a disulfiram‑like reaction.
  • Liver disease: dose adjustment or monitoring may be required.
  • Renal impairment: monitor renal function and adjust dose if needed.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metronidazol Actavis can interact with several medicines; awareness helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Alcohol: may cause severe nausea, vomiting, and flushing.
  • Warfarin: can potentiate anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium concentrations, leading to toxicity.
  • Cimetidine: can increase metronidazole plasma levels.

Moderate Interactions (Monitor Closely)

  • Phenobarbital: may lower metronidazole concentrations, reducing effectiveness.
  • Phenytoin: can decrease metronidazole levels.
  • Oral contraceptives: may reduce hormonal efficacy, requiring additional contraception.

Frequently Asked Questions

Metronidazol Actavis, containing metronidazole, is prescribed for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, various anaerobic bacterial infections, and Clostridioides difficile infection. It targets organisms that thrive in low‑oxygen environments, helping to clear the infection and relieve associated symptoms.

Metronidazole is taken up by anaerobic microorganisms and reduced to nitro radical anions. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to bacterial or protozoal cell death. The selective activation in low‑oxygen cells spares most human tissues.

The specific dose of Metronidazol Actavis is determined by the prescribing clinician based on the infection type, severity, patient age, weight, and renal or hepatic function. Only a qualified healthcare professional should set the dosage regimen.

Safety data for metronidazole in pregnancy are limited, so it should be used only if the potential benefit outweighs any risk. During breastfeeding, metronidazole can be excreted in milk; a healthcare provider should assess whether continuation is appropriate.

To request Metronidazol Actavis, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazole belongs to the nitroimidazole class, which is uniquely effective against anaerobic bacteria and certain protozoa. Unlike many broad‑spectrum antibiotics, it specifically targets low‑oxygen organisms, making it the drug of choice for conditions such as bacterial vaginosis and trichomoniasis where other agents may be less effective.

Metronidazol Actavis should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain stability throughout its shelf life.

Metronidazol Actavis is taken orally, usually with food or a full glass of water to reduce gastrointestinal irritation. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, liver toxicity, and blood dyscrasias. Patients should seek immediate medical attention if they experience neurological symptoms, rash, jaundice, or unexplained bleeding.

Metronidazol Actavis is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, early‑term pregnancy, or those who cannot avoid alcohol during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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