Product image of Metronidazol Actavis (Metronidazole) supplied by GNH India

Metronidazol Actavis

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Actavis (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Actavis, is a nitroimidazole antibiotic presented as a tablet for oral use. It treats infections caused by anaerobic bacteria and certain protozoa in adults and children as prescribed. GNH India supplies Metronidazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Metronidazole is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and protozoa.

  • Bacterial vaginosis: eliminates the anaerobic bacteria responsible for the condition, relieving discharge and odor.
  • Trichomoniasis: eradicates Trichomonas vaginalis, curing the sexually transmitted infection.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Giardiasis: clears Giardia lamblia infection, relieving diarrhoea and abdominal cramps.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding resolution of colitis.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic, skin and soft‑tissue infections.

How It Works

  • Metronidazole enters susceptible anaerobic microorganisms and is reduced by intracellular electron‑transport proteins to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to cell death of anaerobic bacteria and protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Diarrhoea
  • Abdominal pain
  • Loss of appetite

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Pseudomembranous colitis
  • Hepatotoxicity
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia)

Precautions & Warnings

Before prescribing Metronidazol Actavis, clinicians should consider several safety aspects.

  • Renal function: assess kidney status, dose may need adjustment in severe impairment.
  • Hepatic function: monitor liver enzymes, especially in patients with pre‑existing liver disease.
  • Alcohol consumption: advise patients to avoid alcohol due to disulfiram‑like reactions.
  • Pregnancy: use only if benefits outweigh potential risks; safety data are limited.
  • Concomitant medications: review for interactions that may increase toxicity or reduce efficacy.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazol Actavis can affect, or be affected by, several other medicines.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise lithium serum levels, leading to toxicity.
  • Cyclosporine: may increase cyclosporine concentrations, risking nephrotoxicity.
  • Carbamazepine: reduces metronidazole levels, potentially compromising efficacy.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may lower metronidazole concentrations.
  • Phenobarbital: can increase metabolism of metronidazole.
  • Rifampin: induces hepatic enzymes, reducing metronidazole exposure.
  • Cimetidine: may increase metronidazole plasma levels.
  • Oral contraceptives: may reduce hormonal efficacy, advise additional contraception.

Frequently Asked Questions

Metronidazol Actavis contains metronidazole, a nitroimidazole antibiotic indicated for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, Clostridioides difficile infection, and other anaerobic bacterial infections. It is prescribed to eliminate the causative microorganisms and resolve associated symptoms.

Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to cell death. The selective activation in low‑oxygen environments spares most human cells while targeting the pathogens.

The dosage of Metronidazol Actavis is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, and renal or hepatic function. Patients should follow the exact regimen provided by their healthcare professional and not adjust the dose on their own.

Safety data for metronidazole in pregnancy are limited, and the drug is classified as category unknown. It should be used only when the potential benefit justifies any possible risk to the fetus. Metronidazole is excreted in breast milk; nursing mothers should consult their physician before use.

To order Metronidazol Actavis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazol Actavis (metronidazole) and tinidazole belong to the same nitroimidazole class. Both have similar spectra against anaerobes and protozoa, but tinidazole often requires a shorter treatment course due to its longer half‑life. Choice between them depends on local resistance patterns, patient tolerance, and clinician preference.

Metronidazol Actavis tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Metronidazol Actavis is taken orally as a tablet. Patients should swallow the tablet whole with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset in some individuals.

Serious adverse reactions include seizures, peripheral neuropathy, severe allergic responses such as anaphylaxis or Stevens‑Johnson syndrome, pseudomembranous colitis, and hepatotoxicity. Patients should seek immediate medical attention if they experience neurological symptoms, rash, or signs of liver injury while on therapy.

Metronidazol Actavis is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. It should be avoided in patients with severe hepatic impairment and in early pregnancy unless no safer alternative exists. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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