Product image of Metronidazol Actavis (Metronidazole) supplied by GNH India

Metronidazol Actavis

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Actavis (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Actavis, is a nitroimidazole antibiotic presented as an oral tablet for systemic use. It is employed to treat infections caused by anaerobic bacteria and certain protozoa in adult and pediatric patients when indicated by a healthcare professional. Treatment is provided under appropriate clinical guidance and after confirming microbial susceptibility.

GNH India supplies Metronidazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics, and health‑care institutions across multiple regions with reliable quality assurance worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and protozoa.

  • Bacterial vaginosis: eradicates the anaerobic bacteria responsible for the condition, relieving symptoms.
  • Trichomoniasis: eliminates Trichomonas vaginalis, resolving infection and preventing transmission.
  • Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease.
  • Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, skin and soft‑tissue infections.
  • Clostridioides difficile infection: reduces toxin‑producing bacteria, aiding clinical recovery.

How It Works

  • Metronidazole enters susceptible anaerobic cells and is reduced by microbial ferredoxin proteins, generating reactive nitro radicals. These radicals interact with DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a variety of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: mild to moderate headache.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin eruption.
  • Liver toxicity: elevated enzymes or hepatitis.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Pseudomembranous colitis: severe colonic inflammation.

Precautions & Warnings

Before prescribing Metronidazol Actavis, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: excreted in milk; evaluate alternatives.
  • Renal impairment: dose adjustment may be required.
  • Alcohol consumption: may cause a disulfiram‑like reaction.
  • Drug interactions: review concomitant medications for potential effects.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metronidazol Actavis can interact with several medicines; monitoring is essential.

Major Interactions (Avoid)

  • Disulfiram: concurrent use may cause severe reactions.
  • Alcohol: can precipitate a disulfiram‑like response.
  • Warfarin: may increase anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely)

  • Lithium: metronidazole may raise lithium levels.
  • Phenytoin: may reduce metronidazole concentrations.
  • Cimetidine: can increase metronidazole plasma levels.

Frequently Asked Questions

Metronidazol Actavis is prescribed for infections caused by anaerobic bacteria and certain protozoa, including bacterial vaginosis, trichomoniasis, amoebiasis, a range of anaerobic bacterial infections, and Clostridioides difficile infection. The specific indication depends on the clinical diagnosis made by a qualified healthcare professional.

Metronidazole is taken up by anaerobic organisms and reduced to reactive nitro radicals within the cell. These radicals damage DNA and inhibit nucleic acid synthesis, leading to microbial cell death. This mechanism is effective against both anaerobic bacteria and susceptible protozoa.

The exact dose of Metronidazol Actavis is set by the prescribing clinician based on the type and severity of the infection, the patient’s age, weight, renal and hepatic function, and any relevant comorbidities. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for metronidazole in pregnancy are limited, and the drug is generally classified as use‑only if the potential benefit justifies the risk. It is excreted in breast milk, so clinicians usually recommend weighing the benefits against possible infant exposure and may suggest alternative therapy when appropriate.

To order Metronidazol Actavis, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Metronidazol Actavis contains metronidazole, a well‑established nitroimidazole with broad activity against anaerobes and protozoa. Compared with alternatives such as tinidazole, metronidazole has a longer history of use, a well‑characterized safety profile, and is often preferred for first‑line treatment of bacterial vaginosis, trichomoniasis and many anaerobic infections.

Metronidazol Actavis should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metronidazol Actavis is taken orally with a full glass of water. It may be taken with or without food; however, taking it with food can reduce gastrointestinal upset in some patients. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare provider.

Serious adverse reactions include severe allergic responses such as anaphylaxis, neurologic events like seizures or peripheral neuropathy, liver toxicity, and rare skin conditions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, swelling, difficulty breathing, persistent abdominal pain, or neurological symptoms.

Metronidazol Actavis should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, those taking disulfiram, and individuals who consume alcohol heavily, as a disulfiram‑like reaction may occur.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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