Product image of Metronidazol Al (Metronidazole) supplied by GNH India

Metronidazol Al

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Al (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Al, is a nitroimidazole presented as an oral tablet for systemic administration. It is used to treat anaerobic bacterial infections and selected protozoal infections in both adult and pediatric patients when prescribed by a healthcare professional. It is indicated for conditions such as bacterial vaginosis, trichomoniasis, amoebic dysentery and Clostridioides difficile infection.

GNH India supplies Metronidazol Al as a licensed, EU‑origin product that complies with Good Distribution Practice, providing reliable supply to hospitals, pharmacies, specialty and transplant centres worldwide through its international procurement network.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Metronidazole is an antibiotic of the nitroimidazole class that targets anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes and reduces infection‑related symptoms.
  • Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes.
  • Trichomoniasis: eliminates Trichomonas vaginalis, relieving genital discharge and irritation.
  • Amoebic dysentery: kills Entamoeba histolytica trophozoites, controlling intestinal inflammation.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile strains, aiding recovery.

How It Works

  • Metronidazole is taken up by anaerobic microorganisms and reduced by intracellular electron transport proteins to form reactive nitro radicals. These radicals covalently bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to loss of cellular function and ultimately microbial cell death.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing head pain.
  • Diarrhea: loose stools that resolve after therapy.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Peripheral neuropathy: tingling or numbness in extremities, potentially persistent.

Precautions & Warnings

Before prescribing Metronidazol Al, clinicians should consider several safety factors.

  • Renal impairment: assess kidney function and adjust if necessary.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Alcohol consumption: avoid alcohol to prevent a disulfiram‑like reaction.
  • Pregnancy: risk category unknown; weigh benefits against potential risks.
  • Warfarin co‑therapy: monitor INR closely due to possible increased anticoagulant effect.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazol Al can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Alcohol: may cause severe disulfiram‑like reaction.
  • Warfarin: can potentiate anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Lithium: may raise lithium levels, risking toxicity.
  • Cimetidine: can increase metronidazole plasma concentrations.
  • Phenobarbital: may reduce metronidazole effectiveness by enhancing metabolism.

Frequently Asked Questions

Metronidazol Al contains metronidazole, which is prescribed for anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, amoebic dysentery and Clostridioides difficile infection. The drug targets organisms that thrive in low‑oxygen environments and helps eliminate the infection when used as directed by a healthcare professional.

Metronidazole enters susceptible anaerobic bacteria and protozoa and is reduced to reactive nitro radicals. These radicals bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, which leads to loss of cellular function and ultimately microbial cell death.

The specific dose of Metronidazol Al is determined by the prescribing clinician based on the infection being treated, patient age, weight, renal and hepatic function, and other individual factors. Patients should follow the exact regimen provided by their healthcare provider.

The pregnancy safety category for metronidazole is not definitively established. It should only be used during pregnancy or while breastfeeding when the potential benefits outweigh any possible risks, and after a careful assessment by the treating physician.

To place an order, submit an enquiry on the Metronidazol Al product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazol Al belongs to the nitroimidazole class, which is particularly effective against obligate anaerobes and certain protozoa. Compared with broad‑spectrum beta‑lactams, metronidazole offers targeted activity with a lower risk of promoting resistance in aerobic flora, but it is not effective against aerobic Gram‑positive or Gram‑negative organisms.

Metronidazol Al should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability throughout its shelf life.

Metronidazol Al is taken orally, usually with food or a full glass of water to reduce gastrointestinal irritation. The exact administration schedule—such as frequency and duration—must be prescribed by a qualified healthcare professional.

Serious adverse reactions, though rare, can include severe allergic responses (rash, swelling, breathing difficulty), peripheral neuropathy (persistent tingling or numbness), and seizures. Patients should seek immediate medical attention if any of these symptoms develop.

Metronidazol Al is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. Caution is also advised for patients with severe hepatic impairment, and it should be avoided in those who are currently consuming alcohol.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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