Product image of Metronidazol Aurobindo (Metronidazole) supplied by GNH India

Metronidazol Aurobindo

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Aurobindo (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Aurobindo, is a nitroimidazole antibiotic presented as a 0.75% gel for topical (cutaneous) use. It treats rosacea, acne vulgaris and other superficial skin infections caused by susceptible anaerobic bacteria in adults and is applied directly to the affected skin areas.

GNH India supplies Metronidazol Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Metronidazole is used topically to manage conditions involving anaerobic skin bacteria and inflammatory lesions.

  • Rosacea: reduces inflammatory papules and erythema, improving facial appearance.
  • Acne vulgaris: decreases lesion count and severity by targeting Propionibacterium acnes.
  • Superficial skin infections: treats bacterial infections such as folliculitis and impetigo caused by susceptible anaerobes.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by ferredoxin‑type proteins to reactive nitro radicals. These radicals interact with DNA, causing strand breaks and inhibiting nucleic acid synthesis, which leads to bacterial cell death. The selective activation in low‑oxygen environments provides targeted antimicrobial activity while sparing aerobic host cells. The drug also impairs protein synthesis in certain protozoa, contributing to its antiprotozoal effect.

Side Effects

Topical metronidazole may cause a range of local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Dryness: temporary dryness or flaking of treated skin.
  • Burning sensation: transient burning or stinging after application.
  • Pruritus: occasional itching unrelated to underlying condition.

Serious or Rare Side Effects

  • Allergic dermatitis: severe rash, swelling, or hives indicating hypersensitivity.
  • Stevens‑Johnson syndrome: rare but life‑threatening mucocutaneous reaction.
  • Neurotoxicity: peripheral neuropathy or seizures in extreme systemic absorption.
  • Methemoglobinemia: rare blood disorder causing cyanosis.

Precautions & Warnings

When using Metronidazol Aurobindo, several precautions should be observed to ensure safety and effectiveness.

  • Contraindication: avoid use in patients with known hypersensitivity to metronidazole or other nitroimidazoles.
  • Pregnancy: use only if clearly needed; safety data are limited.
  • Breastfeeding: discontinue if infant shows signs of gastrointestinal disturbance.
  • Drug interactions: avoid concurrent alcohol consumption due to disulfiram‑like reaction.
  • Application site: do not apply to broken skin or mucous membranes.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazol Aurobindo can interact with several systemic medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and vomiting (disulfiram‑like reaction).
  • Warfarin: increased anticoagulant effect, raising risk of bleeding.
  • Lithium: elevated lithium levels, potentially causing toxicity.
  • Central nervous system depressants: enhanced sedative effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced effectiveness, consider additional contraception.
  • Phenytoin: may decrease metronidazole plasma levels, reducing efficacy.
  • Cimetidine: can increase metronidazole concentrations, requiring monitoring.

Frequently Asked Questions

Metronidazol Aurobindo is a topical formulation of metronidazole indicated for the treatment of rosacea, acne vulgaris, and other superficial skin infections caused by susceptible anaerobic bacteria. It is applied directly to the affected skin areas to reduce inflammation and bacterial load.

When applied topically, metronidazole penetrates anaerobic microorganisms in the skin and is reduced to reactive nitro radicals. These radicals damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death. The selective activation in low‑oxygen environments provides targeted antimicrobial activity while sparing healthy skin cells.

The specific dose and frequency are determined by the prescribing clinician based on the severity of the condition, patient age, and treatment response. Healthcare professionals tailor the regimen to each individual, and patients should follow the prescriber’s instructions precisely.

Safety data for topical metronidazole in pregnancy are limited, so it should be used only if clearly needed and after risk‑benefit assessment by a healthcare provider. While small amounts are absorbed systemically, breastfeeding mothers should discontinue use if the infant shows gastrointestinal upset or other adverse signs.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metronidazol Aurobindo belongs to the nitroimidazole class, offering both antibacterial and anti‑inflammatory effects. Compared with agents such as clindamycin or benzoyl peroxide, metronidazole has a lower risk of antibiotic resistance and is particularly effective against anaerobic bacteria. Choice of therapy depends on individual patient factors and physician judgment.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

The gel is applied thinly to clean, dry skin once or twice daily, as directed by the prescriber. It should be spread evenly over the affected area and gently massaged until fully absorbed. Hands should be washed after application to avoid inadvertent contact with eyes or mucous membranes.

Serious adverse reactions, although rare, include severe allergic dermatitis, Stevens‑Johnson syndrome, neurotoxicity such as peripheral neuropathy, and methemoglobinemia. Patients should seek immediate medical attention if they experience widespread rash, blistering, numbness, tingling, or unexplained cyanosis.

Individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds should avoid this product. It is also contraindicated on broken skin, mucous membranes, or in patients who are unable to avoid alcohol consumption due to the risk of a disulfiram‑like reaction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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