Product image of Metronidazol Avmc (Metronidazole) supplied by GNH India

Metronidazol Avmc

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol Avmc (Metronidazole)

Metronidazole, the active ingredient in Metronidazol Avmc, is a nitroimidazole presented as an oral tablet for systemic use. It treats anaerobic bacterial and protozoal infections in adults and children as prescribed.
GNH India supplies Metronidazol Avmc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Av Medical Cz S.R.O.

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Indications & Clinical Uses

Metronidazole is used to manage infections caused by anaerobic bacteria and certain protozoa.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic pathogens.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebic dysentery: clears Entamoeba histolytica from the intestinal tract, reducing diarrhea and abdominal pain.
  • Anaerobic bacterial infections: controls mixed‑flora infections such as intra‑abdominal or pelvic abscesses.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by intracellular electron transport proteins. The reduced form generates reactive nitro radicals that damage DNA, inhibit nucleic acid synthesis, and lead to cell death, selectively targeting anaerobic bacteria and susceptible protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: persistent metallic sensation in the mouth.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools during therapy.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Metronidazole requires careful use in several clinical situations.

  • Liver function assessment: evaluate hepatic status before initiating therapy.
  • Neurological monitoring: watch for signs of peripheral neuropathy or seizures.
  • Alcohol avoidance: advise patients to abstain from alcohol during and 48 hours after treatment.
  • Pregnancy considerations: use only if benefits outweigh potential risks, as safety data are limited.
  • Renal dose adjustment: modify dosing in patients with severe renal impairment.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and vomiting.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise lithium serum levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may reduce metronidazole concentrations, decreasing effectiveness.
  • Cimetidine: can increase metronidazole levels, heightening side‑effect potential.
  • Oral contraceptives: may reduce hormonal efficacy, requiring additional contraceptive measures.

Frequently Asked Questions

Metronidazol Avmc, containing metronidazole, is prescribed for bacterial vaginosis, trichomoniasis, amoebic dysentery and other anaerobic bacterial infections such as intra‑abdominal or pelvic infections. It targets organisms that thrive in low‑oxygen environments.

Metronidazole is taken up by anaerobic microbes and reduced by their internal electron transport proteins. This reduction creates reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, leading to microbial cell death while sparing most aerobic cells.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight and renal or hepatic function. Patients should follow the prescriber’s instructions and the product label.

Safety data for metronidazole in pregnancy are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. It is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metronidazole is a nitroimidazole with broad activity against anaerobic bacteria and protozoa, offering a single‑dose or short‑course regimen for many infections. Alternatives such as tinidazole have similar spectra but may differ in dosing frequency, half‑life and side‑effect profiles.

Metronidazol Avmc should be stored at or below 25 °C in a dry place. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging is tightly closed to maintain stability.

The product is supplied as oral tablets that are swallowed whole with a full glass of water. It may be taken with or without food, but taking it with meals can reduce gastrointestinal irritation for some patients.

Serious adverse events include seizures, peripheral neuropathy and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience neurological symptoms, rash, or signs of an allergic response.

Metronidazol Avmc is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles. Caution is also advised for patients with severe hepatic impairment, those taking disulfiram, and individuals who cannot abstain from alcohol during therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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