Product image of Metronidazol B. Braun (Metronidazole) supplied by GNH India

Metronidazol B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazol B. Braun, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections, Clostridioides difficile infection, bacterial vaginosis and amoebiasis in adult patients.

GNH India supplies Metronidazol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Adria D.O.O.

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Indications & Clinical Uses

Metronidazole acts against anaerobic microorganisms and protozoa, making it useful for several infection types.

  • Anaerobic bacterial infections: effective in eradicating susceptible anaerobic organisms.
  • Clostridioides difficile infection: reduces toxin‑producing bacteria and alleviates colitis.
  • Bacterial vaginosis: restores normal vaginal flora by targeting Gardnerella and related species.
  • Amoebiasis: eliminates Entamoeba histolytica trophozoites in invasive disease.

How It Works

  • Metronidazole is taken up by anaerobic bacteria and protozoa, where intracellular reduction converts the nitro group to reactive nitro radicals. These radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, ultimately leading to microbial cell death.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Metallic taste: transient alteration of taste perception.
  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools, usually self‑limiting.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane involvement.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Metronidazole requires careful use in specific clinical situations.

  • Renal impairment: assess kidney function and consider dose adjustment.
  • Hepatic dysfunction: monitor liver enzymes and adjust therapy if needed.
  • Alcohol consumption: avoid alcohol due to disulfiram‑like reaction.
  • Pregnancy: prescribe only when benefits outweigh potential risks.
  • Concurrent warfarin therapy: monitor INR closely for increased anticoagulation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metronidazole can interact with several medicines, influencing safety or efficacy.

Major Interactions (Avoid)

  • Disulfiram: may cause severe disulfiram‑like reaction.
  • Alcohol: can precipitate intense flushing, nausea, and vomiting.
  • Lithium: increased risk of lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: potentiates anticoagulant effect, monitor INR.
  • Phenytoin: may reduce metronidazole plasma levels.
  • Cimetidine: can increase metronidazole concentrations.

Frequently Asked Questions

Metronidazol B. Braun contains metronidazole, which is indicated for anaerobic bacterial infections, Clostridioides difficile infection, bacterial vaginosis, and amoebiasis. It is prescribed when the causative organisms are known to be susceptible to nitroimidazole therapy.

Metronidazole enters anaerobic bacteria and protozoa and is reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to cell death and eradication of the infection.

The specific dose and infusion rate are determined by the treating physician based on the infection type, severity, patient weight, renal and hepatic function, and local prescribing guidelines. No standard dose is provided here.

Metronidazole should be used in pregnancy only when the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms, offering rapid bactericidal activity. Compared with broad‑spectrum beta‑lactams, it has a narrower spectrum but fewer concerns about beta‑lactam resistance and is often preferred for confirmed anaerobic or protozoal infections.

Metronidazol B. Braun should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution before use.

The product is supplied as an injectable solution for intravenous infusion. Administration is performed by a qualified healthcare professional, typically through a peripheral or central line, following aseptic technique and the prescribing clinician’s infusion instructions.

Serious risks include seizures, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatotoxicity, peripheral neuropathy, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and blood count alterations during therapy.

Patients with a known hypersensitivity to metronidazole or other nitroimidazoles should avoid the product. Caution is also advised for individuals with severe hepatic impairment, those taking disulfiram, or patients with a history of seizures unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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