Product image of Metronidazol B. Braun (Metronidazole) supplied by GNH India

Metronidazol B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazol B. Braun, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats anaerobic bacterial and protozoal infections in adult patients.

GNH India supplies Metronidazol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

  • Anaerobic bacterial infections: effective in eliminating susceptible anaerobic organisms and controlling infection.
  • Trichomoniasis: eradicates the protozoan parasite causing vaginal infection.
  • Giardiasis: clears intestinal infection caused by Giardia lamblia.
  • Intra‑abdominal infections: helps resolve polymicrobial infections following surgery or perforation.
  • Pelvic inflammatory disease: contributes to treatment of mixed aerobic‑anaerobic pelvic infections.

How It Works

  • Metronidazole is reduced inside anaerobic microorganisms, forming reactive nitro radical anions that damage DNA and inhibit nucleic acid synthesis. The selective activation in low‑oxygen environments allows it to target anaerobic bacteria and certain protozoa while sparing most aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Dizziness
  • Abdominal discomfort
  • Diarrhea

Serious or Rare Side Effects

  • Seizures
  • Peripheral neuropathy
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome
  • Liver toxicity
  • Neutropenia

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.

  • Renal impairment: adjust therapy based on clinical judgment.
  • Hepatic dysfunction: monitor liver enzymes during treatment.
  • Alcohol consumption: avoid during and at least 48 hours after therapy due to disulfiram‑like reaction.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Concurrent CNS depressants: monitor for additive central nervous system effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metronidazole interacts with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Alcohol: may cause severe disulfiram‑like reaction.
  • Warfarin: increased anticoagulant effect, monitor INR.
  • Lithium: risk of toxicity, monitor serum levels.
  • Cimetidine: may raise metronidazole concentrations.
  • Phenobarbital: may reduce metronidazole efficacy.

Moderate Interactions (Monitor Closely)

  • Erythromycin: possible increased neurotoxicity.
  • Bupropion: heightened seizure risk.
  • Carbamazepine: may decrease metronidazole levels.
  • Theophylline: monitor for enhanced side effects.
  • Oral contraceptives: may reduce effectiveness, advise backup method.

Frequently Asked Questions

Metronidazol B. Braun is indicated for anaerobic bacterial infections, intra‑abdominal infections, pelvic inflammatory disease, and protozoal infections such as trichomoniasis and giardiasis. It is used in hospital settings to manage mixed aerobic‑anaerobic infections and certain parasitic diseases.

Metronidazole enters susceptible anaerobic bacteria and protozoa, where intracellular reduction of its nitro group creates reactive metabolites. These metabolites bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, ultimately leading to cell death.

The dose of Metronidazol B. Braun is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal and hepatic function, and other individual factors. No standard dosing regimen is provided here.

Safety data for Metronidazol B. Braun in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Metronidazol B. Braun belongs to the nitroimidazole class, offering rapid bactericidal activity against strict anaerobes and certain protozoa. Compared with beta‑lactam agents, it provides a broader spectrum for anaerobic coverage and does not require beta‑lactamase stability, but selection depends on infection site and susceptibility patterns.

Store Metronidazol B. Braun at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution. Do not use if the product has been exposed to temperatures outside this range.

Metronidazol B. Braun is administered by intravenous infusion under the supervision of qualified healthcare professionals. The infusion rate and duration are set by the prescriber according to the clinical situation and patient tolerance.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin reactions, and liver function abnormalities during therapy.

Metronidazol B. Braun should be avoided in patients with known hypersensitivity to metronidazole or other nitroimidazoles, in those with severe hepatic impairment unless benefits outweigh risks, and in individuals who have had a disulfiram‑like reaction to alcohol while on therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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