Product image of Metronidazol B. Braun (Metronidazole) supplied by GNH India

Metronidazol B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazol B. Braun, is a nitroimidazole antibiotic presented as a sterile solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adults and children.
GNH India supplies Metronidazol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Metronidazol B. Braun is a nitroimidazole antibiotic used to manage infections caused by anaerobic microorganisms and selected protozoa.

  • Anaerobic bacterial infections: eradicates susceptible anaerobes and reduces infection severity.
  • Clostridioides difficile infection: helps control toxin‑producing C. difficile colitis.
  • Bacterial vaginosis: restores normal vaginal flora by targeting anaerobic pathogens.
  • Amebic liver abscess: eliminates Entamoeba histolytica organisms in hepatic tissue.

How It Works

  • Metronidazole enters anaerobic cells and is reduced by microbial ferredoxin proteins, generating reactive nitro radicals. These free radicals damage DNA, inhibit nucleic acid synthesis, and disrupt essential metabolic pathways, leading to cell death of susceptible anaerobic bacteria and protozoa.

Side Effects

Metronidazol B. Braun may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient alteration of taste perception.
  • Headache: occasional mild to moderate headache.
  • Diarrhea: loose stools that may be self‑limiting.
  • Abdominal pain: cramping or discomfort in the abdomen.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Stevens‑Johnson syndrome: severe skin reaction with blistering.
  • Severe allergic reactions: anaphylaxis, rash, or swelling.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Before using Metronidazol B. Braun, consider the following safety measures.

  • Renal impairment: adjust therapy in patients with reduced kidney function.
  • Hepatic dysfunction: monitor liver enzymes and use cautiously.
  • Alcohol consumption: avoid alcohol to prevent disulfiram‑like reactions.
  • Pregnancy and lactation: assess risk‑benefit, as safety data are limited.
  • Concomitant anticoagulants: monitor coagulation parameters for enhanced bleeding risk.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metronidazol B. Braun can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, and tachycardia.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: may raise lithium serum levels, leading to toxicity.
  • CYP450 inducers (e.g., rifampin): reduce metronidazole plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Phenytoin: may lower metronidazole levels.
  • Carbamazepine: may decrease efficacy of metronidazole.
  • Cimetidine: can increase metronidazole exposure.
  • Oral contraceptives: may reduce hormonal effectiveness, consider backup contraception.

Frequently Asked Questions

Metronidazol B. Braun is indicated for infections caused by anaerobic bacteria and certain protozoa, including anaerobic bacterial infections, Clostridioides difficile colitis, bacterial vaginosis, and amebic liver abscess. It is administered intravenously in hospital settings to achieve rapid systemic concentrations.

Metronidazole is taken up by anaerobic cells and reduced by microbial enzymes, producing nitro radicals that damage DNA and inhibit nucleic acid synthesis. This disruption leads to cell death of susceptible anaerobic bacteria and protozoa.

The specific dose and infusion rate are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local treatment guidelines. Dosage should never be altered without medical advice.

Safety data for metronidazole in pregnancy are limited, and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult a healthcare professional, as the drug can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms, offering rapid bactericidal activity. Compared with broad‑spectrum agents like clindamycin or carbapenems, metronidazole provides a narrower spectrum, which can reduce disruption of normal flora and limit resistance development when the infection is known to be anaerobic.

Metronidazol B. Braun should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from direct light and moisture to maintain stability. Do not freeze the solution.

The product is supplied as a sterile intravenous solution. It is administered by slow infusion into a vein, typically through a peripheral or central line, under the supervision of qualified healthcare personnel. Infusion rates and duration are set by the prescribing clinician.

Serious adverse events include seizures, peripheral neuropathy, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic toxicity, and neutropenia. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and signs of infection or bleeding.

Metronidazol B. Braun is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is also advised for individuals with severe hepatic impairment, those who consume alcohol heavily, and patients receiving disulfiram, due to the risk of severe reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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