Product image of Metronidazol B. Braun (Metronidazole) supplied by GNH India

Metronidazol B. Braun

Active Ingredient:
Metronidazole
Origin:
EU

Metronidazol B. Braun (Metronidazole)

Metronidazole, the active ingredient in Metronidazol B. Braun, is a nitroimidazole antibiotic presented as an injection solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in both adults and children as prescribed by a healthcare professional.

GNH India supplies Metronidazol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Metronidazole is employed to manage infections caused by anaerobic bacteria and susceptible protozoa.
  • Intra‑abdominal infections: eradicates anaerobic organisms, helping resolve infection and inflammation.
  • Pelvic inflammatory disease: eliminates causative anaerobes, reducing pelvic pain and disease progression.
  • Bacterial vaginosis: restores normal vaginal flora by targeting anaerobic bacteria.
  • Sepsis caused by susceptible organisms: provides systemic antibacterial activity to control bloodstream infection.
  • Bacterial meningitis (anaerobic pathogens): penetrates the central nervous system to treat meningitis caused by anaerobes.
  • Protozoal infections (giardiasis, trichomoniasis, amebiasis): destroys protozoa, relieving gastrointestinal or genitourinary symptoms.

How It Works

  • Metronidazole enters anaerobic microorganisms and is reduced by intracellular electron transport proteins to generate nitro radicals. These reactive intermediates damage DNA and inhibit nucleic acid synthesis, leading to cell death. The selective activation in low‑oxygen environments accounts for its effectiveness against anaerobic bacteria and certain protozoa while sparing aerobic cells.

Side Effects

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Headache: occasional dull or throbbing pain.
  • Diarrhea: loose stools that may be self‑limiting.
  • Abdominal pain: cramping or discomfort.
  • Dizziness: light‑headed feeling.

Serious or Rare Side Effects

  • Seizures: rare neurologic events, especially with high doses.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Liver toxicity: elevated enzymes or hepatitis.
  • Blood dyscrasias: agranulocytosis or aplastic anemia.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Assess renal function: adjust therapy in patients with severe renal impairment.
  • Monitor for neurotoxicity: watch for seizures or peripheral neuropathy during treatment.
  • Avoid use in first trimester: limited safety data suggest caution during early pregnancy.
  • Use caution with alcohol: may provoke a disulfiram‑like reaction.
  • Check for drug interactions: especially with warfarin, lithium, and cimetidine.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Metronidazole can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and nausea.
  • Warfarin: potentiates anticoagulant effect, increasing bleeding risk.
  • Lithium: can raise lithium concentrations, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma levels.
  • Phenobarbital: may reduce metronidazole efficacy by inducing metabolism.
  • Bupropion: combined use may increase seizure risk.

Frequently Asked Questions

Metronidazol B. Braun is an intravenous formulation of metronidazole used to treat infections caused by anaerobic bacteria and certain protozoa. Indications include intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, sepsis from susceptible organisms, anaerobic meningitis, and protozoal diseases such as giardiasis, trichomoniasis, and amebiasis.

Metronidazole is reduced inside anaerobic microorganisms to form nitro radicals. These reactive species damage DNA and inhibit nucleic acid synthesis, leading to bacterial or protozoal cell death. The drug’s selective activation in low‑oxygen environments makes it effective against anaerobes while sparing aerobic cells.

The specific dose and infusion rate of Metronidazol B. Braun are determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and other clinical factors. Healthcare providers follow local guidelines and adjust therapy as needed.

Safety data for metronidazole in pregnancy are limited, and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the risk to the fetus. Breastfeeding mothers should consult a physician, as metronidazole can be excreted in breast milk.

To request Metronidazol B. Braun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Metronidazol B. Braun (metronidazole) is a nitroimidazole with strong activity against obligate anaerobes and certain protozoa, offering excellent tissue penetration, including the central nervous system. Compared with beta‑lactam/β‑lactamase inhibitor combinations, metronidazole provides a narrower spectrum focused on anaerobes, often with fewer allergic reactions but with a distinct side‑effect profile such as a disulfiram‑like reaction with alcohol.

Metronidazol B. Braun should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if the container is damaged or the solution appears discolored.

Metronidazol B. Braun is administered intravenously by slow infusion into a vein, usually diluted in compatible IV fluids as directed by the prescriber. Administration should be performed by qualified healthcare personnel in a clinical setting, following aseptic technique and monitoring for any infusion‑related reactions.

Serious risks include seizures, peripheral neuropathy, severe allergic reactions (including anaphylaxis), Stevens‑Johnson syndrome, liver toxicity, and hematologic abnormalities such as agranulocytosis. Patients should be monitored for neurological symptoms, skin changes, liver function abnormalities, and signs of infection or bleeding.

Metronidazol B. Braun is contraindicated in patients with a known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is advised for individuals with severe hepatic or renal impairment, those in the first trimester of pregnancy, and patients with a history of seizures or peripheral neuropathy unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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